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Sirtuin regulation

The buck stops with spermidine

Nature Chemical Biology (2024)Cite this article

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Sirtuins remove post-translationally added acyl groups from protein lysines. New work shows the surprising metabolic fate of acyl groups removed from mitochondrial proteins—they react nonenzymatically with essential polyamine spermidine, forming previously unknown monoacylated N-glutarylspermidines and diacylated N-glutaryl,N-acetylspermidines.

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Fig. 1: Protein deacylation in mitochondria produces N-acylspermidines.

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  1. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Anthony J. Michael

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  1. Anthony J. Michael
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Correspondence to Anthony J. Michael.

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Michael, A.J. The buck stops with spermidine. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-023-01510-3

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