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Genome Editing

Voyage to minimal base editors

Nature Chemical Biology volume 18, pages 920–921 (2022)Cite this article

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An Author Correction to this article was published on 16 February 2023

This article has been updated

Cas12f1 is a member of type V Cas12 family, which has a hypercompact size. A Cas12f1-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

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Fig. 1: Size comparison of diverse Cas nucleases and TnpB.

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Authors and Affiliations

  1. Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul, South Korea

    Beomjong Song

  2. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea

    Sangsu Bae

  3. Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, South Korea

    Sangsu Bae

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  1. Beomjong Song
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  2. Sangsu Bae
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Correspondence to Sangsu Bae.

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The authors declare no competing interests.

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Song, B., Bae, S. Voyage to minimal base editors. Nat Chem Biol 18, 920–921 (2022). https://doi.org/10.1038/s41589-022-01101-8

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