Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RNA MODIFICATIONS

A dual function PUS enzyme

Nature Chemical Biology volume 16, pages 107–108 (2020)Cite this article

Subjects

The traditional function of pseudouridine synthases is to convert uridine residues in RNA to pseudouridines. A study reveals a new function for the human PUS10 protein, which enhances micro-RNA maturation in addition to tRNA modification.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: PUS10 bridges the cellular processes of miRNA processing with tRNA modification.

References

  1. Song, J. H. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-019-0420-5 (2020).

  2. Li, X., Ma, S. & Yi, C. Curr. Opin. Chem. Biol. 33, 108–116 (2016).

    Article  CAS  Google Scholar 

  3. Fitzek, E., Joardar, A., Gupta, R. & Geisler, M. J. Mol. Evol. 86, 77–89 (2018).

    Article  CAS  Google Scholar 

  4. Jana, S., Hsieh, A. C. & Gupta, R. Cell Death Dis. 8, e3093 (2017).

    Article  Google Scholar 

  5. Guzzi, N. et al. Cell 173, 1204–1216.e26 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, University of Chicago, Chicago, IL, USA

    Wen Zhang

  2. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA

    Tao Pan

Authors
  1. Wen Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tao Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tao Pan.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, W., Pan, T. A dual function PUS enzyme. Nat Chem Biol 16, 107–108 (2020). https://doi.org/10.1038/s41589-019-0450-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-019-0450-z

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing