The mechanisms of many disease-associated variants are uncertain because of limited power to detect their modest effects on gene expression. This study finds that natural selection leads to preferential detection of disease-associated versus expression-associated variants.
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Amariuta, T. The power paradox of detecting disease-associated and gene-expression-associated variants. Nat Genet 55, 1782–1783 (2023). https://doi.org/10.1038/s41588-023-01525-5
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DOI: https://doi.org/10.1038/s41588-023-01525-5