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Cancer evolution

A systematic analysis of immune escape signals in the primary and metastatic tumor genome

Nature Genetics volume 55, pages 728–729 (2023)Cite this article

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Tumors develop mechanisms to escape immune destruction. A systematic analysis of large genome sequencing datasets shows that one in four tumors develop genetic immune escape and its prevalence is remarkably similar between primary and metastatic tumors, suggesting that immune escape is an early event during tumor evolution.

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Fig. 1: GIE in primary and metastatic tumors.

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Authors and Affiliations

  1. Department of Human Structure and Repair, Anatomy and Embryology Unit, Ghent University, Ghent, Belgium

    Jimmy Van den Eynden

  2. Cancer Research Institute Ghent, Ghent, Belgium

    Jimmy Van den Eynden

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  1. Jimmy Van den Eynden
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Correspondence to Jimmy Van den Eynden.

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The author declares no competing interests.

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Van den Eynden, J. A systematic analysis of immune escape signals in the primary and metastatic tumor genome. Nat Genet 55, 728–729 (2023). https://doi.org/10.1038/s41588-023-01374-2

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