A study uses single-cell RNA sequencing to profile human papillomavirus (HPV)-positive and -negative oropharyngeal squamous cell carcinoma, revealing considerable diversity within and between tumors. Within HPV-positive tumors, subsets of malignant cells are found with undetectable HPV expression and decreased HPV-related phenotypes, which may influence prognosis and response to therapy.
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Peace, D.J., Izumchenko, E. & Sidransky, D. Unexpected heterogeneity in oropharyngeal squamous cell tumors. Nat Genet 55, 534–535 (2023). https://doi.org/10.1038/s41588-023-01360-8
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DOI: https://doi.org/10.1038/s41588-023-01360-8