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DISEASE GENETICS

ADCY3, neuronal primary cilia and obesity

Nature Geneticsvolume 50pages166167 (2018) | Download Citation

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Two new studies identify rare homozygous variants in ADCY3 that are causal for monogenic obesity in consanguineous families of Pakistani origin and are associated with increased risk of obesity in Greenlandic individuals. Greenlandic carriers of homozygous loss-of-function variants in ADCY3, and individuals from trans-ancestry studies with a burden of rare ADCY3 loss-of-function variants, also have increased risk of type 2 diabetes.

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References

  1. 1

    Locke, A. E. et al. Nature 518, 197–206 (2015).

  2. 2

    Speliotes, E. K. et al. Nat. Genet. 42, 937–948 (2010).

  3. 3

    Saeed, S. et al. Nat. Genet. https://doi.org/10.1038/s41588-017-0023-6 (2018).

  4. 4

    Warrington, N. M. et al. Int. J. Epidemiol. 44, 700–712 (2015).

  5. 5

    Grarup, N. et al. Nat Genet. https://doi.org/10.1038/s41588-017-0022-7 (2018).

  6. 6

    Moltke, I. et al. Nature 512, 190–193 (2014).

  7. 7

    Tong, T., Shen, Y., Lee, H. W., Yu, R. & Park, T. Sci. Rep. 6, 34179 (2016).

  8. 8

    Wong, S. T. et al. Neuron 27, 487–497 (2000).

  9. 9

    Wang, Z. et al. PLoS One 4, e6979 (2009).

  10. 10

    Bishop, G. A., Berbari, N. F., Lewis, J. & Mykytyn, K. J. Comp. Neurol. 505, 562–571 (2007).

  11. 11

    Cao, H., Chen, X., Yang, Y. & Storm, D. R. Integr. Obes. Diabetes 2, 225–228 (2016).

  12. 12

    Reiter, J. F. & Leroux, M. R. Nat. Rev. Mol. Cell Biol. 18, 533–547 (2017).

  13. 13

    Siljee, J. E. et al. Nat Genet. https://doi.org/10.1038/s41588-017-0020-9 (2018).

  14. 14

    Wu, L., Shen, C., Seed Ahmed, M., Östenson, C. G. & Gu, H. F. Obes. Rev. 17, 907–914 (2016).

  15. 15

    Hong, S. H. et al. Oncotarget 4, 1791–1803 (2013).

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Affiliations

  1. Wellcome Trust Sanger Institute, Cambridge, UK

    • Inês Barroso

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The author declares no competing financial interests.

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Correspondence to Inês Barroso.

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DOI

https://doi.org/10.1038/s41588-018-0043-x

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