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GENE REGULATION

Pioneering the chromatin landscape

Nature Geneticsvolume 50pages167169 (2018) | Download Citation

New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.

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Affiliations

  1. Institute for Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania Smilow Center for Translational Research, Philadelphia, PA, USA

    • Kenneth S. Zaret

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The author declares no competing financial interests.

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Correspondence to Kenneth S. Zaret.

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DOI

https://doi.org/10.1038/s41588-017-0038-z

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