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Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials

Nature Biotechnology volume 42, pages 563–569 (2024)Cite this article

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Although the clinical application of induced pluripotent stem cells is still in its infancy, the development of iPSC technologies reflected by an increasing number of patents provides hope that they will realize their therapeutic potential.

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Fig. 1: General temporal trend of iPSC technology-related patents and clinical trials.
Fig. 2: Temporal and geographic distribution of iPSC technologies.
Fig. 3: Organizational affiliations of iPSC-related patents.
Fig. 4: Technological distribution of iPSC-related patents.
Fig. 5: Time trend in different technological categories.

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Acknowledgements

This research was supported with the Ministry of Science and Technology National Key R&D grant (2022YFA1105000), National Science Foundation China general grant (32270842), Macau Science and Technology Development Fund (FDCT) grants (0002-2021-AKP and 0071-2022-A2), University of Macau (UM) grants (CPG2024-00037-FHS, MYRG2020-00140-FHS and MYRG2022-00044-FHS) to R.X., as well as FDCT grants (005/2023/SKL and SKL-QRCM(UM)-2023-2025), UM grants (MYRG2022-00103-ICMS and MYRG-CRG2023-00007-ICMS-IAS) and Zhuhai UM Science & Technology Research Institute grant (CP-033-2021) to Y.J.H.

Author information

Author notes

  1. These authors contributed equally: Liyang Lyu, Ye Feng, Borong Huang.

Authors and Affiliations

  1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China

    Liyang Lyu, Ye Feng & Yuanjia Hu

  2. Center of Reproduction, Development & Aging, and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China

    Borong Huang & Ren-He Xu

  3. Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macao SAR, China

    Borong Huang & Ren-He Xu

  4. DPM, Faculty of Health Sciences, University of Macau, Macao SAR, China

    Yuanjia Hu

  5. Centre for Pharmaceutical Regulatory Sciences, University of Macau, Macao SAR, China

    Yuanjia Hu

Authors
  1. Liyang Lyu
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  2. Ye Feng
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  3. Borong Huang
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  4. Ren-He Xu
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Corresponding authors

Correspondence to Ren-He Xu or Yuanjia Hu.

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The authors declare no competing interests.

Supplementary information

Supplementary Information

Supplementary Methods, Supplementary Fig 1

Supplementary Data

Listing of 11,252 patents

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Lyu, L., Feng, Y., Huang, B. et al. Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials. Nat Biotechnol 42, 563–569 (2024). https://doi.org/10.1038/s41587-024-02196-1

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