Cells differentiate to their final fates through sequential epigenetic and transcriptional changes. A mathematical model fit on multi-omic single-cell data yields insights into the temporal relationships between chromatin accessibility and gene expression during cell differentiation.
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This is a summary of: Li, C., Virgilio, M. C., Collins, K. L. & Welch, J. D. Multi-omic single-cell velocity models epigenome–transcriptome interactions and improves cell fate prediction. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01476-y (2022).
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Mathematical modeling of epigenetic gene regulation during cell differentiation. Nat Biotechnol 41, 330–331 (2023). https://doi.org/10.1038/s41587-022-01488-8
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DOI: https://doi.org/10.1038/s41587-022-01488-8