Correction to: Nature https://doi.org/10.1038/s41586-022-04403-y Published online 9 February 2022

In the version of this article initially published, there were errors in the affiliations shown for Colorectal Cancer Domain UK 100,000 Genomes Project members Steve Thorn and Henry Wood. Steve Thorn is with the Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK (not University of Leeds). Henry Wood is with Pathology and Data Analytics, Leeds Institute of Medical Research, St James’s University Hospital, University of Leeds, Leeds, UK (not The University of Edinburgh). The errors have been corrected in the HTML and PDF versions of the article.