In 2019, the Bladder Cancer Molecular Taxonomy Group (BCMTG) presented a consensus molecular classification comprising six subtypes of muscle-invasive bladder cancer (MIBC). The non-luminal subtypes were the most consistent with previous models. Subsequent studies in 2019 have revealed molecular heterogeneity among the luminal subtypes and their possible clinical ramifications.
Key advances
In 2019, the Bladder Cancer Molecular Taxonomy Group put substantial effort into providing a consensus molecular classification comprising six subtypes of muscle-invasive bladder cancer (MIBC).
The consensus classifier contains three luminal subtypes.
In 2019, three studies were published in which the luminal subtype could be subdivided further by either immunohistochemistry, long non-coding RNA expression or pathological upstaging.
Moreover, tumour samples with variant histology (nested or micropapillary) fall into the luminal subgroup but have an aggressive disease course.
Consequently, future subtyping studies should reveal which classification approach is the best for clinical decision-making.
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References
Kamoun, A. et al. A consensus molecular classification of muscle-invasive bladder cancer. Eur. Urol. https://doi.org/10.1016/j.eururo.2019.09.006 (2019).
Robertson, A. G. et al. Comprehensive molecular characterization of muscle-invasive bladder cancer. Cell 171, 540–556 (2017).
Sjodahl, G. et al. A molecular taxonomy for urothelial carcinoma. Clin. Cancer Res. 18, 3377–3386 (2012).
Bernardo, C. et al. Molecular pathology of the luminal class of urothelial tumors. J. Pathol. 249, 308–318 (2019).
Seiler, R. et al. Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy. Eur. Urol. 72, 544–554 (2017).
Lotan, Y. et al. Molecular subtyping of clinically localized urothelial carcinoma reveals lower rates of pathological upstaging at radical cystectomy among luminal tumors. Eur. Urol. 76, 200–206 (2019).
Gibb, E. A., Brown, C. J. & Lam, W. L. The functional role of long non-coding RNA in human carcinomas. Mol. Cancer 10, 38 (2011).
de Jong, J. J. et al. Long non-coding RNAs identify a subset of luminal muscle-invasive bladder cancer patients with favorable prognosis. Genome Med. 11, 60 (2019).
Guo, C. C. et al. Gene expression profile of the clinically aggressive micropapillary variant of bladder cancer. Eur. Urol. 70, 611–620 (2016).
Weyerer, V. et al. Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma. Histopathology https://doi.org/10.1111/his.13958 (2019).
Acknowledgements
The authors thank J. L. Boormans for helpful suggestions on the manuscript and E. A. Gibb for helpful suggestions on the manuscript and personal communication.
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de Jong, J.J., Zwarthoff, E.C. Molecular and clinical heterogeneity within the luminal subtype. Nat Rev Urol 17, 69–70 (2020). https://doi.org/10.1038/s41585-019-0262-7
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DOI: https://doi.org/10.1038/s41585-019-0262-7
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