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KIDNEY CANCER

Disagreement in risk groups for metastatic renal cancer

In patients with metastatic renal cell carcinoma, risk stratification according to the Memorial Sloan Kettering Cancer Center or the International Metastatic Renal Cell Carcinoma Database Consortium classification systems is a crucial part of clinical assessment and essential for guiding management. New research has now demonstrated that disagreement in risk-group classification is common and prognostically relevant.

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References

  1. Motzer, R. J. et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J. Clin. Oncol. 20, 289–296 (2002).

    Article  CAS  Google Scholar 

  2. Heng, D. Y. C. et al. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J. Clin. Oncol. 27, 5794–5799 (2009).

    Article  CAS  Google Scholar 

  3. Ljungberg, B. et al. EAU guidelines: renal cell carcinoma. uroweb http://uroweb.org/guideline/renal-cell-carcinoma (2019).

  4. Harrell, F. E. Problems caused by categorizing continuous variables. Vanderbilt University http://biostat.mc.vanderbilt.edu/wiki/Main/CatContinuous (2019).

  5. Noe, A. et al. Comparison of pre-treatment MSKCC and IMDC prognostic risk models in patients with synchronous metastatic renal cell carcinoma treated in the era of targeted therapy. World J. Urol. 34, 1067–1072 (2016).

    Article  CAS  Google Scholar 

  6. Okita, K. et al. Impact of disagreement between two risk group models on prognosis in patients with metastatic renal cell carcinoma. Clin. Genitourin. Cancer https://doi.org/10.1016/j.clgc.2019.01.006 (2019).

    Article  PubMed  Google Scholar 

  7. Méjean, A. et al. Sunitinib alone or after nephrectomy in metastatic renal-cell carcinoma. N. Engl. J. Med. 379, 417–427 (2018).

    Article  Google Scholar 

  8. Heng, D. Y. C. et al. Cytoreductive nephrectomy in patients with synchronous metastases from renal cell carcinoma: results from the International Metastatic Renal Cell Carcinoma Database Consortium. Eur. Urol. 66, 704–710 (2014).

    Article  Google Scholar 

  9. Motzer, R. J. et al. Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N. Engl. J. Med. 378, 1277–1290 (2018).

    Article  CAS  Google Scholar 

  10. Motzer, R. J. et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 356, 115–124 (2007).

    Article  CAS  Google Scholar 

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Correspondence to Tobias Klatte.

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Klatte, T., Stewart, G.D. Disagreement in risk groups for metastatic renal cancer. Nat Rev Urol 16, 332–333 (2019). https://doi.org/10.1038/s41585-019-0174-6

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