A novel autoantigen, calponin-3, was identified in the serum of a patient with Sjögren syndrome (SS) by mass spectrometry peptide sequencing. Anti-calponin-3 antibodies were then detected in patients with SS (11% of patients), systemic lupus erythematosus (8.7%), myositis (5.1%) and multiple sclerosis (6.8%). In patients with SS, the frequency of these antibodies was highest in those with neuropathies. Calponin-3 was expressed in perineuronal satellite cells.
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Birnbaum, J. et al. Anti-calponin-3 autoantibodies: a new specificity in patients with Sjögren’s syndrome. Arthritis Rheum. https://doi.org/10.1002/art.40550 (2018)
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Leake, I. Novel autoantibody in Sjögren syndrome. Nat Rev Rheumatol 14, 384 (2018). https://doi.org/10.1038/s41584-018-0028-2
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DOI: https://doi.org/10.1038/s41584-018-0028-2
