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Alzheimer disease

Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy

Nature Reviews Neurology (2024)Cite this article

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Success in a trial of low-intensity ultrasound combined with an amyloid-β antibody represents a major stride towards integrating pharmacological and nonpharmacological approaches to reduce the amyloid-β load in patients with mild Alzheimer disease. This trial also highlights the potential of therapeutic ultrasound modalities to combat neurodegenerative diseases.

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Fig. 1: Mechanism of action and bioeffects of individual treatments that were combined in the trial.

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  1. Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia

    Jürgen Götz & Pranesh Padmanabhan

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  1. Jürgen Götz
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  2. Pranesh Padmanabhan
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Correspondence to Jürgen Götz.

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Götz, J., Padmanabhan, P. Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy. Nat Rev Neurol (2024). https://doi.org/10.1038/s41582-024-00943-1

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