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NEUROIMMUNOLOGY

The complexity of neuroinflammation at single-cell resolution

Nature Reviews Neurology volume 15, pages 249–250 (2019)Cite this article

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A new study, using a mouse model of multiple sclerosis, applied single-cell RNA sequencing to determine how immune cells in the CNS respond during inflammation. In addition to highlighting novel subtypes of cells that evolve over the course of disease, the findings have important implications for developing targeted therapies for inflammatory demyelinating diseases.

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Fig. 1: Myeloid cell heterogeneity during inflammation.

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Authors and Affiliations

  1. Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Ravikiran M. Raju

  2. Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA

    Li-Huei Tsai

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  1. Ravikiran M. Raju
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  2. Li-Huei Tsai
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Correspondence to Li-Huei Tsai.

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The authors declare no competing interests.

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Raju, R.M., Tsai, LH. The complexity of neuroinflammation at single-cell resolution. Nat Rev Neurol 15, 249–250 (2019). https://doi.org/10.1038/s41582-019-0165-5

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