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GLOMERULAR DISEASE

A step forward in understanding glomerular filtration

Nature Reviews Nephrology volume 16, pages 431–432 (2020)Cite this article

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The mechanism underlying glomerular filtration barrier selectivity has not been resolved. A new study that reports an inverse correlation between slit diaphragm density and proteinuria in a genetic mouse model of focal segmental glomerulosclerosis suggests that podocytes function to compress the glomerular basement membrane (GBM) and that failure of this process results in GBM stretching and increased permeability.

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Fig. 1: Mechanisms coupling slit diaphragm density and proteinuria.

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Authors and Affiliations

  1. Department of Nephrology and Clinical Immunology, RWTH Aachen University Clinic, Aachen, Germany

    Marcus J. Moeller & Arnaldo Chia-Gil

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  1. Marcus J. Moeller
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  2. Arnaldo Chia-Gil
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Correspondence to Marcus J. Moeller.

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The authors declare no competing interests.

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Moeller, M.J., Chia-Gil, A. A step forward in understanding glomerular filtration. Nat Rev Nephrol 16, 431–432 (2020). https://doi.org/10.1038/s41581-020-0313-6

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