This Genome Watch article highlights how single-cell sequencing has transformed the approaches to understand schistosome developmental biology.
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Single-cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem-cell regulators
Scientific Reports Open Access 12 March 2024
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References
Wang, B. et al. Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni. Elife 10, e35449 (2018).
Li, P. et al. Single-cell analysis of Schistosoma mansoni identifies a conserved genetic program controlling germline stem cell fate. Nat. Commun. 12, 485 (2021).
Wendt, G. et al. A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding. Science 369, 1644–1649 (2020).
Diaz Soria, C. L. et al. Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni. Nat. Commun. 11, 6411 (2020).
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Rinaldi, G., Attenborough, T., Rawlinson, K.A. et al. Schistosomes go single cell. Nat Rev Microbiol 20, 705 (2022). https://doi.org/10.1038/s41579-022-00810-0
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DOI: https://doi.org/10.1038/s41579-022-00810-0