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The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vertebrate hosts.
Apicomplexa include important human pathogens and possess a unique cellular machinery that promotes gliding motility and is called the glideosome. In this Review, Soldati-Favre and colleagues discuss the principles that govern gliding motility, the characterization of the molecular machinery that comprises the glideosome, and its impact on parasite invasion and egress from infected cells.
Quorum-sensing-mediated interactions between Trypanosoma congolense and Trypanosoma brucei promote the differentiation of T. brucei into transmissible ‘stumpy forms’, suggesting that cross-species interactions during co-infections modulate disease dynamics.
A recent study by Silvester et al. found that a conserved quorum sensing signalling pathway regulates interspecies crosstalk in trypanosome co-infections and provided novel insights into trypanosome virulence and transmission.