Organs in the human body have complex networks of fluid-filled tubes and loops with different geometries and topologies. By studying self-organized, synthetic tissues, the link between topological transitions and the emergence of tissue architecture was revealed.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Karzburn, E. et al. Human brain organoids on a chip reveal the physics of folding. Nat. Phys. 14, 515–522 (2018). This paper reports how folds can self-organize in human brain organoids.
Palmer, M. A. et al. Stress ball morphogenesis: How the lizard builds its lung. Sci. Adv. 7, eabk0161 (2021). This paper reports how fluid pressure deforms an epithelial sheet into the complex architecture of lizard lungs.
Collinet, C. & Lecuit, T. Programmed and self-organized flow of information in morphogenesis. Nat. Rev. Mol. Cell Bio. 22, 245–265 (2021). A review article that presents the current view of biophysical and biochemical mechanisms in morphogenesis.
Chartier, N. T. et al. A hydraulic instability drives the cell death decision in the nematode germline. Nat. Phys. 17, 920–925 (2021). This paper reports how hydraulic exchanges between germ cells determine which cells develop into oocytes.
Campàs, O. A toolbox to explore the mechanics of living embryonic tissues. Semin. Cell Dev. Biol. 55, 119–130 (2016). A review article that presents techniques for studying the role of mechanics in living tissues.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Ishihara, K. et al. Topological morphogenesis of neuroepithelial organoids. Nat. Phys. https://doi.org/10.1038/s41567-022-01822-6 (2022).
Rights and permissions
About this article
Cite this article
Topological control of synthetic morphogenesis. Nat. Phys. 19, 163–164 (2023). https://doi.org/10.1038/s41567-022-01843-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41567-022-01843-1