Human skin organoids are susceptible to mpox virus infection and support infectious virus production. Treatment of infected skin organoids with the antiviral drug tecovirimat can inhibit infectious virus production and prevent host transcriptome rewiring. Thus, skin-organoid-based models are robust for studying mpox virus infection and testing therapeutics.
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References
Americo, J. L., Earl, P. L. & Moss, B. Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model. Proc. Natl Acad. Sci. USA 120, e2220415120 (2023). This paper reports the virulence differences of mpox virus clades I and II.
Li, P. et al. Clinical features, antiviral treatment, and patient outcomes: a systematic review and comparative analysis of the previous and the 2022 mpox outbreaks. J. Infect. Dis. 228, 391–401 (2023). A systematic review article describing the clinical features of patients with mpox.
Rosa, R. B. et al. In vitro and in vivo models for monkeypox. iScience 26, 105702 (2023). A review article that presents the current experimental models for MPXV research.
Lee, J. et al. Hair-bearing human skin generated entirely from pluripotent stem cells. Nature 582, 399–404 (2020). This paper reports a protocol on how to generate human skin organoids from pluripotent stem cells.
Sherwat, A. et al. Tecovirimat and the treatment of monkeypox — past, present, and future considerations. N. Engl. J. Med. 387, 579–581 (2022). This article provides an overview of tecovirimat for treating smallpox and mpox diseases.
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This is a summary of: Li, P. et al. Mpox virus infection and drug treatment modelled in human skin organoids. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01489-6 (2023).
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Human skin organoids are valid models of mpox virus infection. Nat Microbiol 8, 1950–1951 (2023). https://doi.org/10.1038/s41564-023-01490-z
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DOI: https://doi.org/10.1038/s41564-023-01490-z
