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Microbiome

Tracking microbiota fibre breakdown to treat NASH

Nature Microbiology volume 8, pages 1382–1383 (2023)Cite this article

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Tracking the journey of inulin, a soluble dietary fibre, reveals its fate and transformation by the gut microbiota to alleviate liver disease in mice.

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Fig. 1: P. distasonis uses inulin to produce pentadecanoic acid and ameliorate NASH in mice.

References

  1. Zhao, L. et al. Science 359, 1151–1156 (2018).

    Article  CAS  PubMed  Google Scholar 

  2. Roager, H. M. et al. Gut 68, 83–93 (2019).

    Article  CAS  PubMed  Google Scholar 

  3. Wei, W. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01418-7 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Aoki, R. et al. Microbiome 9, 188 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Delannoy-Bruno, O. et al. Nature 595, 91–95 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Pérez-Monter, C. et al. Int. J. Mol. Sci. 23, 991 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Wang, K. et al. Cell Rep. 26, 222–235 (2019).

    Article  PubMed  Google Scholar 

  8. Weitkunat, K. et al. Am. J. Clin. Nutr. 105, 1544–1551 (2017).

    Article  CAS  PubMed  Google Scholar 

  9. Tilg, H. et al. Cell Metab. 34, 1700–1718 (2022).

    Article  CAS  PubMed  Google Scholar 

  10. Rodriguez, J. et al. Gut 69, 1975–1987 (2020).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This study has been supported by the Spanish Ministry of Science and Innovation (MICINN) (grant PID2020-119536RB-I00). The Miguel Servet contract to M.O. is acknowledged.

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Authors and Affiliations

  1. Microbiome, Nutrition & Health Research Unit, Institute of Agrochemistry and Food Technology, Severo Ochoa Centre of Excellence, National Research Council, Valencia, Spain

    Alejandra Flor-Duro, Marta Olivares & Yolanda Sanz

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  1. Alejandra Flor-Duro
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  2. Marta Olivares
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  3. Yolanda Sanz
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Correspondence to Yolanda Sanz.

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The authors declare no competing interests.

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Flor-Duro, A., Olivares, M. & Sanz, Y. Tracking microbiota fibre breakdown to treat NASH. Nat Microbiol 8, 1382–1383 (2023). https://doi.org/10.1038/s41564-023-01440-9

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