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Bacterial pathogenesis

Epigenetic modifications influence urinary tract infection outcome

Nature Microbiology volume 8, pages 764–766 (2023)Cite this article

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Bladder epithelial cells exposed to uropathogenic Escherichia coli infection have long-lasting epigenetic modifications linked with inflammation that influence host susceptibility to subsequent infections.

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Fig. 1: Mice challenged with UPEC either self-resolve infection (resolved/resistant) or are unable to clear primary infection and develop recurrent chronic infection (sensitized/susceptible).

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Authors and Affiliations

  1. Department of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

    Soumitra Mohanty, John Kerr White & Annelie Brauner

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  1. Soumitra Mohanty
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  2. John Kerr White
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  3. Annelie Brauner
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All authors contributed equally to the writing of this manuscript.

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Correspondence to Annelie Brauner.

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The authors declare no competing interests.

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Mohanty, S., White, J.K. & Brauner, A. Epigenetic modifications influence urinary tract infection outcome. Nat Microbiol 8, 764–766 (2023). https://doi.org/10.1038/s41564-023-01371-5

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