Infection by Mycobacterium tuberculosis (Mtb) induces remodelling of the host-cell transcriptome, which is mediated by epigenetic mechanisms. Histone acetylation of KCNJ15 stimulates transcription and the activation of genes implicated in apoptosis to promote Mtb clearance.
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25 February 2022
A Correction to this paper has been published: https://doi.org/10.1038/s41564-022-01087-y
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Carless, M.A., Schlesinger, L.S. Mycobacterium tuberculosis remodels host transcriptome. Nat Microbiol 7, 189–190 (2022). https://doi.org/10.1038/s41564-021-01056-x
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DOI: https://doi.org/10.1038/s41564-021-01056-x