A high-fat diet causes gut microbiota dysbiosis and depletion of the microbial metabolite indole-3-acetic acid in a murine model, resulting in decreased antibiotic efficacy against bacterial infections.
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References
Butler, M. S. & Paterson, D. L. J. Antibiot. (Tokyo) 73, 329–364 (2020).
Liu, Y. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-021-00912-0 (2021).
Vogt, S. L., Peña-Díaz, J. & Finlay, B. B. Anaerobe 34, 106–115 (2015).
Wu, G. D. et al. Science 334, 105–108 (2011).
Simpson, H. L. & Campbell, B. J. Aliment. Pharmacol. Ther. 42, 158–179 (2015).
Hryckowian, A. J. et al. Nat. Microbiol. 3, 662–669 (2018).
Ng, K. M. et al. Cell Host Microbe 26, 650–665 (2019).
Oliveira, R. A. et al. Nat. Microbiol. 5, 630–641 (2020).
Song, S. & Wood, T. K. Front. Microbiol. 11, 1565 (2020).
Thompson, J. A., Oliveira, R. A., Djukovic, A., Ubeda, C. & Xavier, K. B. Cell Rep. 10, 1861–1871 (2015).
Acknowledgements
We acknowledge the Portuguese national funding agency Fundação para a Ciência e Tecnologia (FCT) for individual grant nos. IF/00831/2015, PD/BD/106000/2014 and SFRH/BPD/116806/2016 to K.B.X., R.A.O. and V.C., respectively, and the project PTDC/BIA‐MIC/6990/2020.
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Oliveira, R.A., Cabral, V. & Xavier, K.B. Microbiome–diet interactions drive antibiotic efficacy. Nat Microbiol 6, 824–825 (2021). https://doi.org/10.1038/s41564-021-00926-8
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DOI: https://doi.org/10.1038/s41564-021-00926-8