Cryptic halogenation reactions result in natural products with diverse structural motifs and bioactivities. However, these halogenated species are difficult to detect with current analytical methods because the final products are often not halogenated. An approach to identify products of cryptic halogenation using halide depletion has now been discovered, opening up space for more effective natural product discovery.
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Sehnal, L., Lo Presti, L. & Ziemert, N. Discovering cryptic natural products by substrate manipulation. Nat. Chem. 16, 149–151 (2024). https://doi.org/10.1038/s41557-023-01433-5
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DOI: https://doi.org/10.1038/s41557-023-01433-5