Genetic code expansion beyond α-amino acids is a major challenge, in which stitching together non-natural building blocks within the ribosome is a critical barrier. Now, the molecular determinants for the efficient incorporation of non-natural amino acids into the ribosome have been unlocked, accelerating ribosomal synthesis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chin, J. W. Nature 550, 53–60 (2017).
Watson, Z. L. et al. Nat. Chem. https://doi.org/10.1038/s41557-023-01226-w (2023).
Sievers, A., Beringer, M., Rodnina, M. V. & Wolfenden, R. Proc. Natl Acad. Sci. USA 101, 7897–7901 (2004).
Sinha, S., Pindi, C., Ahsan, M., Arantes, P. R. & Palermo, G. J. Chem. Theory Comput. 19, 1945–1964 (2023).
Polikanov, Y. S., Steitz, T. A. & Innis, C. A. Nat. Struct. Mol. Biol. 21, 787–793 (2014).
Pichkur, E. B. et al. RNA 26, 715–723 (2020).
Watson, Z. L. et al. eLife 9, (2020).
Laio, A. & Parrinello, M. Proc. Natl Acad. Sci. USA 99, 12562–12566 (2002).
Burgi, H. B., Dunitz, J. D., Lehn, J. M. & Wipff, G. Tetrahedron 30, 1563–1572 (1974).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Sinha, S., Ahsan, M. & Palermo, G. Establishing the fundamental rules for genetic code expansion. Nat. Chem. 15, 892–893 (2023). https://doi.org/10.1038/s41557-023-01243-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-023-01243-9