Acutely damaged lysosomes can regenerate themselves by repurposing damaged membranes. After damage, cytosolic TBC1D15 relocalizes to impaired lysosomes and assembles the autophagic lysosomal reformation machinery to drive this regeneration. This mechanism exemplifies an immediate cellular response to mitigate the crisis of severe lysosomal damage.
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References
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This is a summary of: Bhattacharya, A. et al. A lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01125-9 (2023).
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TBC1D15 drives regeneration of acutely damaged lysosomes. Nat Cell Biol 25, 639–640 (2023). https://doi.org/10.1038/s41556-023-01135-7
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DOI: https://doi.org/10.1038/s41556-023-01135-7
