Haematopoietic stem cells (HSCs) are maintained in vivo by intrinsic programs and extrinsic niche signals. Ex vivo expansion of HSCs is limited, owing to reduced stem cell maintenance factors. A study now shows that rejuvenated niche cells can be obtained by transcriptional rewiring of specific genes that maintain and expand HSCs ex vivo.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Méndez-Ferrer, S. et al. Nature 466, 829–834 (2010).
Zhao, M. et al. Cell Rep. 26, 652–669.e656 (2019).
Ding, L., Saunders, T. L., Enikolopov, G. & Morrison, S. J. Nature 481, 457–462 (2012).
Greenbaum, A. et al. Nature 495, 227–230 (2013).
Kumar, S. & Geiger, H. Trends Mol. Med. 23, 799–819 (2017).
Morrison, S. J. & Kimble, J. Nature 441, 1068–1074 (2006).
Nakahara, F. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0308-3 (2019).
Wei, Q. & Frenette, P. S. Immunity 48, 632–648 (2018).
Bianco, P., Robey, P. G. & Simmons, P. J. Cell Stem Cell 2, 313–319 (2008).
Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G. & Morrison, S. J. Cell Stem Cell 15, 154–168 (2014).
Li, H. et al. Proc. Natl. Acad. Sci. USA 105, 9397–9402 (2008).
Boitano, A. E. et al. Science 329, 1345–1348 (2010).
Li, Z. et al. Cell Res. 28, 904–917 (2018).
Perry, J. M. et al. Genes Dev. 25, 1928–1942 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
L.L. and several lab members are inventors on the following patents/patent applications: “Methods, kits and compositions for stem cell self-renewal,” “PTEN/Akt methods and compositions relating to BMP,” “Methods for treating chemoresistant cancer-initiating cells,” “Methods and systems useful in culturing hematopoietic stem cells,” and “Methods of identifying stem cells in normal and cancerous tissues and related progeny.” The patents and patent applications are all assigned to the Stowers Institute for Medical Research. L.L. and the other inventors are entitled to share of any proceeds generated by the intellectual property. Currently, none of the above are actively licensed.
Rights and permissions
About this article
Cite this article
Venkatraman, A., Li, L. Niche cells rewired to maintain HSCs ex vivo. Nat Cell Biol 21, 540–541 (2019). https://doi.org/10.1038/s41556-019-0322-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-019-0322-5