Macrophages modulate mammary tumour response to chemotherapy. A new study shows that targeted elimination of macrophages elicits a type I interferon response in the tumour microenvironment that enhances the efficacy of platinum- but not taxane-based chemotherapy, underscoring complex regulatory roles for macrophages in chemotherapy-treated tumours.
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M.D.P. reports honoraria from Merck and Sanofi/Regeneron Pharmaceuticals, received sponsored research grants from Hoffmann La-Roche, MedImmune and Deciphera Pharmaceuticals and serves on the Scientific Advisory Boards of Deciphera Pharmaceuticals and Genenta.
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De Palma, M., Nassiri, S. & Cianciaruso, C. Macrophage interference on chemotherapy. Nat Cell Biol 21, 411–412 (2019). https://doi.org/10.1038/s41556-019-0303-8
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DOI: https://doi.org/10.1038/s41556-019-0303-8
