Paraspeckles are nuclear bodies built on the long noncoding RNA, NEAT1, that regulate cellular homeostasis, but how they sense and help under stress is unclear. A study now shows mitochondrial stress modulates paraspeckles by altering NEAT1 expression with a feedback loop that influences mitochondrial homeostasis.
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References
Fox, A. H., Nakagawa, S., Hirose, T. & Bond, C. S. Trends Biochem. Sci. 43, 124–135 (2018).
Prasanth, K. V. et al. Cell 123, 249–263 (2005).
Chen, L. L. & Carmichael, G. G. Mol. Cell 35, 467–478 (2009).
Hirose, T. et al. Mol. Biol. Cell 25, 169–183 (2014).
Mello, S. S. et al. Genes Dev 31, 1095–1108 (2017).
Imamura, K. et al. Mol. Cell 53, 393–406 (2014).
Nakagawa, S. et al. Development 141, 4618–4627 (2014).
Adriaens, C. et al. Nat. Med. 22, 861–868 (2016).
Nishimoto, Y. et al. Mol. Brain 6, 31 (2013).
Wang, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0204-2 (2018).
Lau, E. & Ronai, Z. A. J. Cell Sci. 15, 2815–2824 (2012).
Naganuma, T. et al. EMBO J. 31, 4020–4034 (2012).
Shelkovnikova, T. A. et al. Mol. Neurodegener. 13, 30 (2018).
Malhotra, J. D. & Kaufman, R. J. Cold Spring Harb. Perspec. Biol. 3, a004424 (2011).
Yamazaki, T. et al. Mol. Cell 70, 1038–1053 (2018).
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Fox, A.H. A mitochondria–paraspeckle crosstalk. Nat Cell Biol 20, 1108–1109 (2018). https://doi.org/10.1038/s41556-018-0207-z
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DOI: https://doi.org/10.1038/s41556-018-0207-z