Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.
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Guan, W. Probing when dCas9 tolerates DNA mismatches. Nat. Biomed. Eng 8, 207–208 (2024). https://doi.org/10.1038/s41551-023-01172-5
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DOI: https://doi.org/10.1038/s41551-023-01172-5
