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STEM CELL CULTURE

Cheaper and less variable expansion

Nature Biomedical Engineering volume 2, pages 144–145 (2018)Cite this article

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Substituting growth factors with small molecules in the culture medium for the expansion of human pluripotent stem cells reduces costs and lot-to-lot variability.

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Fig. 1: A cost-effective and reproducible medium for the culture of hPSCs.

References

  1. Adil, M. M. & Schaffer, D. V. Curr. Opin. Chem. Eng. 15, 24–35 (2017).

    Article  Google Scholar 

  2. Yasuda, S.-y. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0200-7 (2018).

  3. Hasegawa, K. et al. Stem Cells Transl. Med. 1, 18–28 (2011).

  4. Sokol, S. Y. Development 138, 4341–4350 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Li, X. et al. Cell Stem Cell 8, 46–58 (2011).

    Article  CAS  PubMed  Google Scholar 

  6. Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H. & Fuchs, E. Cell 132, 299–310 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Merkle, F. T. et al. Nature 545, 229–233 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Weinberger, L., Ayyash, M., Novershtern, N. & Hanna, J. H. Nat. Rev. Mol. Cell Biol. 17, 155–169 (2016).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA, USA

    Maroof M. Adil & David V. Schaffer

  2. Departments of Bioengineering and Molecular and Cell Biology, and the Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA

    David V. Schaffer

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  1. Maroof M. Adil
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  2. David V. Schaffer
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Correspondence to David V. Schaffer.

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Adil, M.M., Schaffer, D.V. Cheaper and less variable expansion. Nat Biomed Eng 2, 144–145 (2018). https://doi.org/10.1038/s41551-018-0209-y

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