Here we show that photoexcited blue light receptor cryptochrome 2 (CRY2) mediates blue light-induced liquid–liquid phase separation (LLPS) of CRY2–SPA1–FIO1 trimolecular complexes. This activates the N6-methyladenosine (m6A) writer FIONA1 (FIO1) to methylate mRNAs that encode chloroplast proteins, which are required for maintaining chlorophyll homeostasis and photosynthesis in response to light.
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References
Shi, H. et al. Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol. Cell 74, 640–650 (2019). A review article that presents m6A methylation on eukaryotic mRNA.
Tang, J. et al. Detection, regulation, and functions of RNA N6-methyladenosine modification in plants. Plant Commun. 4, 100546 (2023). A review article that discusses m6A methylation in plants.
Wang, Q. & Lin, C. Mechanisms of cryptochrome-mediated photoresponses in plants. Annu. Rev. Plant Biol. 71, 103–129 (2020). A review article that presents blue light signalling transduction in plants.
Wang, X. et al. A photoregulatory mechanism of the circadian clock in. Arabidopsis. Nat. Plants 7, 1397–1408 (2021). A review article that discusses how blue light-induced CRY2–MTA LLPS regulates the circadian clock in plants.
Han, D. et al. Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation. PLoS Biol. 20, e3001535 (2022). An article that shows how LLPS regulates dynamic assembly of the mRNA–m6A methyltransferase complex.
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This is a summary of: Jiang, B. et al. Light-induced LLPS of the CRY2–SPA1–FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis. Nat. Plants https://doi.org/10.1038/s41477-023-01580-0 (2023).
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Light-induced protein condensation regulates chlorophyll homeostasis. Nat. Plants 9, 1952–1953 (2023). https://doi.org/10.1038/s41477-023-01579-7
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DOI: https://doi.org/10.1038/s41477-023-01579-7
