Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Surgical approach to endophthalmitis: an overview

Abstract

Endophthalmitis is one of the most severe ocular emergencies faced by ophthalmologists worldwide. Without prompt treatment significant visual loss is inevitable. With increased understanding of the science of endophthalmitis, recent studies have shown a clear role of early and more definitive surgery to achieve better visual and anatomic outcomes. Surgery in endophthalmitis encompasses a whole gamut of interventions. There are diagnostic procedures like anterior chamber tap and vitreous biopsy or therapeutic procedures like complete pars plana vitrectomy and retinal detachment repair. Current literature is deficient on a detailed description of the spectrum of surgical interventions in endophthalmitis. In the current communication, we summarize the studies based on various surgical interventions in endophthalmitis. We also elaborate in detail on each surgical maneuver, taking the reader through the nuances of each surgery via an exhaustive description and appropriate photos and surgical video clips.

摘要

眼内炎为全球眼科医生面临的最严重的眼科急症。若不及时治疗, 将不可避免地导致严重的视力丧失。随着对眼内炎了解的不断加深, 最近的研究表明, 病程早期和更加完善的手术治疗对患者的功能以及解剖预后疗效显著。眼内炎手术形式多样。在诊断方面, 可进行前房穿刺和玻璃体活检;在治疗方面, 可行彻底的经睫状体平坦部玻璃体切除和视网膜脱离复位术。目前缺乏对眼内炎手术干预范围的详细描述的文献。就目前的研究现状, 本文总结了各种基于眼内炎手术干预的临床研究, 并详细阐述了手术操作的步骤, 并通过详细解读、术中图片以及剪辑的手术视频, 使读者了解每一次手术的细微差别。

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Pre and post slit lamp photo of anterior chamber membrane cleared in endophthalmitis.
Fig. 2: Pre and post slit lamp photo of IOL explantation for low-grade endophthalmitis.
Fig. 3: Slit lamp photograph demonstrating different cases of lens abscesses.
Fig. 4: A case of endophthalmitis post open globe injury with hazy cornea which underwent endoscopic vitrectomy.

Similar content being viewed by others

References

  1. Dave TV, Dave VP, Sharma S, Karolia R, Joseph J, Pathengay A, et al. Infectious endophthalmitis leading to evisceration: spectrum of bacterial and fungal pathogens and antibacterial susceptibility profile. J Ophthalmic Inflamm Infect. 2019;9:9.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Results of the Endophthalmitis Vitrectomy Study. A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. Endophthalmitis Vitrectomy Study Group. Arch Ophthalmol. 1995;113:1479–96.

  3. Kuhn F, Gini G. Vitrectomy for endophthalmitis. Ophthalmology. 2006;113:714.

    Article  PubMed  Google Scholar 

  4. Sheng Y, Sun W, Gu Y, Lou J, Liu W. Endophthalmitis after cataract surgery in China, 1995-2009. J Cataract Refract Surg. 2011;37:1715–22.

    Article  PubMed  Google Scholar 

  5. Behera UC, Budhwani M, Das T, Basu S, Padhi TR, Barik MR, et al. Role Of Early Vitrectomy In The Treatment Of Fungal Endophthalmitis. Retina. 2018;38:1385–92.

    Article  PubMed  Google Scholar 

  6. Sjoholm-Gomez de Liano C, Soberon-Ventura VF, Salcedo-Villanueva G, Santos-Palacios A, Guerrero-Naranjo JL, Fromow-Guerra J, et al. Sensitivity, specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis. Eye Vis. 2017;4:18.

    Article  Google Scholar 

  7. Dave VP, Parmeshwarappa DC, Dogra A, Pappuru RR, Pathengay A, Joseph J, et al. Clinical Presentations and Comparative Outcomes of Delayed-Onset Low-Grade Endophthalmitis Managed with or Without Intraocular Lens Explantation. Clin Ophthalmol. 2020;14:551–5.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Mangan MS, Arıcı C, Tuncer İ, Yetik H. Isolated Anterior Lens Capsule Rupture Secondary to Blunt Trauma: Pathophysiology and Treatment. Turk J Ophthalmol. 2016;46:197–9.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lobo A, Lightman S. Vitreous aspiration needle tap in the diagnosis of intraocular inflammation. Ophthalmology. 2003;110:595–9.

    Article  PubMed  Google Scholar 

  10. Sharma S, Jalali S, Adiraju MV, Gopinathan U, Das T. Sensitivity and predictability of vitreous cytology, biopsy, and membrane filter culture in endophthalmitis. Retina. 1996;16:525–9.

    Article  CAS  PubMed  Google Scholar 

  11. Raju B, Das T, FRCS The Hyderabad Endophthalmitis Research Group. Simple And Stable Technique Of Vitreous Tap. Retina. 2004;24:803–5.

    Article  PubMed  Google Scholar 

  12. Dave VP, Vithalani N, Sheba E, Joseph J, Pathengay A. Culture Positivity Rates Of Deep Vitreous Biopsy Under Air Vis-À-Vis Conventional Anterior Vitreous Biopsy In Endogenous Endophthalmitis. Retina. 2022;42:2128–33.

    Article  PubMed  Google Scholar 

  13. Koch FH, Koss MJ. Microincision vitrectomy procedure using intrector technology. Arch Ophthalmol. 2011;129:1599–604.

    Article  PubMed  Google Scholar 

  14. Kim J, Kim HS, Yoo SJ, Choi MJ, Lew Y, Kim JW, et al. Immediate Vitrectomy for Acute Endophthalmitis in Patients with a Visual Acuity of Hand Motion or Better. Korean J Ophthalmol. 2022;36:390–7.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Jeong SH, Cho HJ, Kim HS, Han JI, Lee DW, Kim CG, et al. Acute endophthalmitis after cataract surgery: 164 consecutive cases treated at a referral center in South Korea. Eye. 2017;31:1456–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Jackson TL, Eykyn SJ, Graham EM, Stanford MR. Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases. Surv Ophthalmol. 2003;48:403–23.

    Article  PubMed  Google Scholar 

  17. Venkatesh P, Temkar S, Tripathy K, Chawla R. Intralesional antibiotic injection using 41G needle for the management of subretinal abscess in endogenous endophthalmitis. Int J Retin Vitreous. 2016;2:17.

    Article  Google Scholar 

  18. Maguire J. Postoperative endophthalmitis: optimal management and the role and timing of vitrectomy surgery. Eye. 2008;22:1290–1300.

    Article  CAS  PubMed  Google Scholar 

  19. Inoue M, Shinoda K, Shinoda H, Kawamura R, Suzuki K, Ishida S. Two-step oblique incision during 25-gauge vitrectomy reduces incidence of postoperative hypotony. Clin Exp Ophthalmol. 2007;35:693–6.

    Article  PubMed  Google Scholar 

  20. Dave VP, Joseph J, Jayabhasker P, Pappuru RR, Pathengay A, Das T. Does ophthalmic-grade silicone oil possess antimicrobial properties? J Ophthalmic Inflamm Infect. 2019;9:20.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hegazy HM, Kivilcim M, Peyman GA, Unal MH, Liang C, Molinari LC, et al. Evaluation of toxicity of intravitreal ceftazidime, vancomycin, and ganciclovir in a silicone oil-filled eye. Retina. 1999;19:553–7.

    CAS  PubMed  Google Scholar 

  22. Radhika M, Mithal K, Bawdekar A, Dave V, Jindal A, Relhan N, et al. Pharmacokinetics of intravitreal antibiotics in endophthalmitis. J Ophthalmic Inflamm Infect. 2014;4:22.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Majji AB, Jalali S, Das T, Gopinathan U. Role of intravitreal dexamethasone in exogenous fungal endophthalmitis. Eye. 1999;13:660–5.

    Article  PubMed  Google Scholar 

Download references

Funding

Funding

This study is funded by the Hyderabad Eye Research Foundation

Author information

Authors and Affiliations

Authors

Contributions

The study was conceived and designed by Vivek Pravin Dave and Aiswarya Ramachandran. All authors were involved in the draft, proof reading and finalizing the manuscript.

Corresponding author

Correspondence to Vivek Pravin Dave.

Ethics declarations

Competing interests

The authors declare no competing interests.

Informed consent

Permission has been received from the patient(s) shown in Figs. 14 for the use of their image in published media.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ramachandran, A., Das, T., Pathengay, A. et al. Surgical approach to endophthalmitis: an overview. Eye (2024). https://doi.org/10.1038/s41433-024-03089-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41433-024-03089-y

Search

Quick links