Abstract
Background
Uveal melanoma (UM) is the most common primary ocular tumour in adults. The most used eye-preserving treatments are charged-particle therapy (CPT) and brachytherapy. We performed a systematic review and meta-analysis to compare efficacies and complications of these two radiotherapies.
Methods
We searched EMBASE, PubMed, MEDLINE, and the Cochrane Library from January 2012 to December 2022. Two independent reviewers identified controlled studies comparing outcomes of CPT versus brachytherapy. Case series that utilize either treatment modality were also reviewed.
Results
One hundred fifty studies met the eligibility criteria, including 2 randomized control trials, 5 controlled cohort studies, and 143 case series studies. We found significant reduction in local recurrence rate among patients treated with CPT compared to brachytherapy (Odds ratio[OR] 0.38, 95% Confidence interval [CI] 0.24ā0.60, pā<ā0.01). Analysis also showed a trend of increased risks of secondary glaucoma after CPT. No statistically significant differences were found in analyzing risks of mortality, enucleation, and cataract.
Conclusions
Our study suggested no difference in mortality, enucleation rate and cataract formation rate comparing the two treatments. Lower local recurrence rate and possibly higher secondary glaucoma incidence was noted among patients treated with CPT. Nevertheless, the overall level of evidence is limited, and further high-quality studies are necessary to provide a more definitive conclusion.
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Data availability
This study is registered was registered with PROSPERO (ID:399075.) Extracted data are available online(link); additional requests may be made to the corresponding author.
References
Shields JA, Shields CL. Intraocular Tumors: A Text and Atlas. Saunders; 1992.
Diener-West M, Earle J, Fine S, Hawkins B, Moy C, Reynolds S, et al. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, II: characteristics of patients enrolled and not enrolled. COMS Report No. 17. Arch Ophthalmol. 2001;119:951ā65.
Group TCOMS. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings: COMS Report No. 18. Arch Ophthalmol. 2001;119:969ā82.
Ghassemi F, Sheibani S, Arjmand M, Poorbaygi H, Kouhestani E, Sabour S, et al. Comparison of iodide-125 and ruthenium-106 brachytherapy in the treatment of choroidal melanomas. Clin Ophthalmol. 2020;14:339ā46.
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, et al. Roadmap: helium ion therapy. Phys Med Biol. 2022;67:15TR02.
Char DH, Phillips T, Daftari I. Proton teletherapy of uveal melanoma. Int Ophthalmol Clin. 2006;46:41ā49.
Tommasino F, Scifoni E, Durante M. New ions for therapy. Int J Part Ther. 2016;2:428ā38.
Damato BE. Treatment selection for uveal melanoma. Dev Ophthalmol. 2012;49:16ā26.
Zemba M, Dumitrescu OM, Gheorghe AG, Radu M, Ionescu MA, Vatafu A, et al. Ocular complications of radiotherapy in uveal melanoma. Cancers. 2023;15:333.
Allen AM, Pawlicki T, Dong L, Fourkal E, Buyyounouski M, Cengel K, et al. An evidence based review of proton beam therapy: the report of ASTROās emerging technology committee. Radiother Oncol. 2012;103:8ā11.
Park JM, Kim JI, Wu HG. Technological advances in charged-particle therapy. Cancer Res Treat. 2021;53:635ā40.
Harbour JW, Char DH, Kroll S, Quivey JM, Castro J. Metastatic risk for distinct patterns of postirradiation local recurrence of posterior uveal melanoma. Ophthalmology. 1997;104:1785ā92.
Lin AJ, Rao YJ, Acharya S, Schwarz J, Rao PK, Grigsby P. Patterns of care and outcomes of proton and eye plaque brachytherapy for uveal melanoma: review of the national cancer database. Brachytherapy. 2017;16:1225ā31.
Char DH, Kroll S, Phillips TL, Quivey JM. Late radiation failures after iodine 125 brachytherapy for uveal melanoma compared with charged-particle (proton or helium ion) therapy. Ophthalmology. 2002;109:1850ā4.
Char DH, Quivey JM, Castro JR, Kroll S, Phillips T. Helium ions versus iodine 125 brachytherapy in the management of uveal melanoma. A prospective, randomized, dynamically balanced trial. Ophthalmology. 1993;100:1547ā54.
Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev. 2019;10:Ed000142.
Sterne JA, HernĆ”n MA, Reeves BC, SavoviÄ J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919.
Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, et al. Chapter 7: Systematic reviews of etiology and risk. Joanna briggs institute reviewerās manual, vol 5. The Joanna Briggs Institute; 2021. pp. 217ā69.
Mishra KK, Quivey JM, Daftari IK, Weinberg V, Cole TB, Patel K, et al. Long-term results of the UCSF-LBNL randomized trial: charged particle with helium ion versus iodine-125 plaque therapy for choroidal and ciliary body melanoma. Int J Radiat Oncol Biol Phys. 2015;92:376ā83.
Bolling JP, Dagan R, Rutenberg M, Mamalui-Hunter M, Buskirk SJ, Heckman MG, et al. Treatment of uveal melanoma with radioactive iodine 125 implant compared with proton beam radiotherapy. Mayo Clin Proc Innov Qual Outcomes. 2022;6:27ā36.
Wilson MW, Hungerford JL. Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma. Ophthalmology. 1999;106:1579ā87.
Kowal J, Markiewicz A, DÄbicka-Kumela M, Bogdali A, Jakubowska B, Karska-Basta I, et al. Analysis of local recurrence causes in uveal melanoma patients treated with (125)I brachytherapy - a single institution study. J Contemp Brachytherapy. 2019;11:554ā62.
Oxenreiter MM, Lane AM, Aronow MB, Shih H, Trofimov AV, Kim IK, et al. Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field). Br J Ophthalmol. 2022;106:518ā21.
Hussain RN, Chiu A, Pittam B, Taktak A, Damato BE, Kacperek A, et al. Proton beam radiotherapy for choroidal and ciliary body melanoma in the UK-national audit of referral patterns of 1084 cases. Eye. 2022;37:1033ā6.
Guleser UY, Sarici AM, Ucar D, Gonen B, Sengul Samanci N, ĆzgĆ¼roÄlu M. Comparison of iodine-125 plaque brachytherapy and gamma knife stereotactic radiosurgery treatment outcomes for uveal melanoma patients. Graefes Arch Clin Exp Ophthalmol. 2022;260:1337ā43.
Mazzini C, Pieretti G, Vicini G, Nicolosi C, Scoccianti S, Pertici M, et al. Clinical outcomes and secondary glaucoma after gamma-knife radiosurgery and Ruthenium-106 brachytherapy for uveal melanoma: a single institution experience. Melanoma Res. 2021;31:38ā48.
Cennamo G, Montorio D, DāAndrea L, Farella A, Matano E, Giuliano M, et al. Long-term outcomes in uveal melanoma after ruthenium-106 brachytherapy. Front Oncol. 2021;11:754108.
Hauzinger JA, Blatsios G, Haas G, Zehetner C, Velez-Escola L, Nowosielski Y, et al. Proton beam radiation for iris melanoma: case series and review of literature. BMJ Open Ophthalmol. 2021;6:e000683.
Fili M, Astrahan M, StĆ„lhammar G. Long-term outcomes after enucleation or plaque brachytherapy of choroidal melanomas touching the optic disc. Brachytherapy. 2021;20:1245ā56.
Sobti MM, Edington M, Connolly J, McLernon DJ, Schipani S, Ritchie D, et al. Outcomes following notched ruthenium-106 plaque brachytherapy for juxtapapillary choroidal melanomas. Ocul Oncol Pathol. 2021;7:411ā7.
Marinkovic M, Pors LJ, van den Berg V, Peters FP, Schalenbourg A, Zografos L, et al. Clinical outcomes after international referral of uveal melanoma patients for proton therapy. Cancers. 2021;13:6241.
Meidenbauer K, Richards Z, Yupari RJ, Bena JF, Wilkinson A, Suh J, et al. Outcomes for posterior uveal melanoma: validation of american brachytherapy society guidelines. Brachytherapy. 2021;20:1226ā34.
Zhou N, Zhang R, Liu Y, Wei W. Clinical characteristics of UM and association of metastasis of uveal melanoma with congenital oculocutaneous melanosis in asian patients: analysis of 1151 consecutive eyes. Ophthalmol Retina. 2021;5:1164ā72.
Yupari RJ, Bena J, Wilkinson A, Suh J, Singh A. Small choroidal melanoma: outcomes following apical height dose brachytherapy. Br J Ophthalmol. 2021;105:1161ā5.
Xu TT, Pulido JS, Deufel CL, Corbin KS, Petersen IA, Dalvin LA. Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma. Eye. 2021;35:2754ā62.
Jampol LM, Moy CS, Murray TG, Reynolds SM, Albert DM, Schachat AP, et al. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS Report No. 19. Ophthalmology. 2020;127:S148ās157.
Jung SK, Park YH, Shin DH, Kim HS, Jung JH, Kim TH, et al. Visual outcomes of proton beam therapy for choroidal melanoma at a single institute in the Republic of Korea. PLoS ONE. 2020;15:e0242966.
FilƬ M, Trocme E, Bergman L, See TRO, AndrĆ© H, Bartuma K, et al. Ruthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ā„5.5 mm. Br J Ophthalmol. 2020;104:26ā32.
Jiang P, Purtskhvanidze K, Kandzia G, Neumann D, Luetzen U, Siebert FA, et al. (106)Ruthenium eye plaque brachytherapy in the management of medium sized uveal melanoma. Radiat Oncol. 2020;15:183.
Riechardt AI, Stroux A, Seibel I, Heufelder J, Zeitz O, Bƶhmer D, et al. Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve. Graefes Arch Clin Exp Ophthalmol. 2020;258:2523ā33.
StƄlhammar G. Forty-year prognosis after plaque brachytherapy of uveal melanoma. Sci Rep. 2020;10:11297.
ToutƩe A, Angi M, Dureau S, LƩvy-Gabriel C, Rouic LL, Dendale R, et al. Long-term visual outcomes for small uveal melanoma staged T1 treated by proton beam radiotherapy. Cancers. 2019;11:1047.
Espensen CA, Appelt AL, Fog LS, Gothelf AB, Thariat J, Kiilgaard JF. Predicting visual acuity deterioration and radiation-induced toxicities after brachytherapy for choroidal melanomas. Cancers. 2019;11:1124.
King BA, Awh C, Gao BT, Wang J, Kocak M, Morales-Tirado VM, et al. Iodine-125 episcleral plaque brachytherapy for AJCC T4 posterior uveal melanoma: clinical outcomes in 158 patients. Ocul Oncol Pathol. 2019;5:340ā9.
StĆ„lhammar G, See TR, FilƬ M, Seregard S. No gender differences in long-term survival after brachytherapy of 1,541 patients with uveal melanoma. Ocul Oncol Pathol. 2019;5:432ā9.
AlMahmoud T, Quinlan-Davidson S, Pond GR, DeschĆŖnes J. Outcome analysis of visual acuity and side effect after ruthenium-106 plaque brachytherapy for medium-sized choroidal melanoma. Middle East Afr J Ophthalmol. 2018;25:103ā7.
Danish H, Ferris MJ, Balagamwala E, Switchenko JM, Patel KR, Choudhary M, et al. Comparative outcomes and toxicities for ruthenium-106 versus palladium-103 in the treatment of choroidal melanoma. Melanoma Res. 2018;28:120ā5.
Seibel I, Riechardt AI, Erb-Eigner K, Bƶker A, Cordini D, Heufelder J, et al. Proton beam irradiation: a safe procedure in postequatorial extraocular extension from uveal melanoma. Am J Ophthalmol. 2018;191:49ā53.
Le BHA, Kim JW, Deng H, Rayess N, Jennelle RL, Zhou SY, et al. Outcomes of choroidal melanomas treated with eye physics plaques: A 25-year review. Brachytherapy. 2018;17:981ā9.
Miguel D, de Frutos-Baraja JM, LĆ³pez-Lara F, Saornil MA, GarcĆa-Ćlvarez C, Alonso P, et al. Radiobiological doses, tumor, and treatment features influence on outcomes after epiescleral brachytherapy. A 20-year retrospective analysis from a single-institution: part II. J Contemp Brachytherapy. 2018;10:347ā59.
Oellers P, Mowery YM, Perez BA, Stinnett S, Mettu P, Vajzovic L, et al. Efficacy and safety of low-dose iodine plaque brachytherapy for juxtapapillary choroidal melanoma. Am J Ophthalmol. 2018;186:32ā40.
Pagliara MM, Tagliaferri L, Azario L, Lenkowicz J, Lanza A, Autorino R, et al. Ruthenium brachytherapy for uveal melanomas: Factors affecting the development of radiation complications. Brachytherapy. 2018;17:432ā8.
Shields CL, Sioufi K, Srinivasan A, Di Nicola M, Masoomian B, Barna LE, et al. Visual outcome and millimeter incremental risk of metastasis in 1780 patients with small choroidal melanoma managed by plaque radiotherapy. JAMA Ophthalmol. 2018;136:1325ā33.
Aziz HA, Al Zahrani YA, Bena J, Lorek B, Wilkinson A, Suh J, et al. Episcleral brachytherapy of uveal melanoma: role of intraoperative echographic confirmation. Br J Ophthalmol. 2017;101:747ā51.
Bellerive C, Aziz HA, Bena J, Wilkinson A, Suh JH, Plesec T, et al. Local failure after episcleral brachytherapy for posterior uveal melanoma: patterns, risk factors, and management. Am J Ophthalmol. 2017;177:9ā16.
Hegde JV, McCannel TA, McCannel CA, Lamb J, Wang PC, Veruttipong D, et al. Juxtapapillary and circumpapillary choroidal melanoma: globe-sparing treatment outcomes with iodine-125 notched plaque brachytherapy. Graefes Arch Clin Exp Ophthalmol. 2017;255:1843ā50.
Papakostas TD, Lane AM, Morrison M, Gragoudas ES, Kim IK. Long-term outcomes after proton beam irradiation in patients with large choroidal melanomas. JAMA Ophthalmol. 2017;135:1191ā6.
Patel KR, Prabhu RS, Switchenko JM, Chowdhary M, Craven C, Mendoza P, et al. Visual acuity, oncologic, and toxicity outcomes with (103)Pd vs. (125)I plaque treatment for choroidal melanoma. Brachytherapy. 2017;16:646ā53.
Riechardt AI, Karle B, Cordini D, Heufelder J, Budach V, Joussen AM, et al. Proton therapy of iris melanoma with 50 CGE : Influence of target volume on clinical outcome. Strahlenther Onkol. 2017;193:943ā50.
Rospond-Kubiak I, WrĆ³blewska-Zierhoffer M, Twardosz-Pawlik H, KociÄcki J. Ruthenium brachytherapy for uveal melanoma - single institution experience. J Contemp Brachytherapy. 2017;9:548ā52.
Tagliaferri L, Pagliara MM, Masciocchi C, Scupola A, Azario L, Grimaldi G, et al. Nomogram for predicting radiation maculopathy in patients treated with Ruthenium-106 plaque brachytherapy for uveal melanoma. J Contemp Brachytherapy. 2017;9:540ā7.
Zewar A, Nawaiseh I, Jaradat I, Khzouz J, Alrawashdeh K, Abdeen G, et al. Management and outcome of uveal melanoma in a single tertiary cancer center in Jordan. Turk Patoloji Derg. 2016;32:186ā92.
BelaĆÆd A, Nasr C, Jmour O, Cherif A, Kochbati L, Bouguila H, et al. Brachytherapy of uveal melanomas with ruthenium-106 plaques. Asian Pac J Cancer Prev. 2016;17:5281ā5.
Bensoussan E, Thariat J, Maschi C, Delas J, Schouver ED, HĆ©rault J, et al. Outcomes after proton beam therapy for large choroidal melanomas in 492 patients. Am J Ophthalmol. 2016;165:78ā87.
Caminal JM, PadrĆ³n-PĆ©rez N, Arias L, Masuet-Aumatell C, GutiĆ©rrez C, Piulats JM, et al. Transscleral resection without hypotensive anaesthesia vs iodine-125 plaque brachytherapy in the treatment of choroidal melanoma. Eye. 2016;30:833ā42.
Thariat J, Grange JD, Mosci C, Rosier L, Maschi C, Lanza F, et al. Visual outcomes of parapapillary uveal melanomas following proton beam therapy. Int J Radiat Oncol Biol Phys. 2016;95:328ā35.
Marinkovic M, Horeweg N, Fiocco M, Peters FP, Sommers LW, Laman MS, et al. Ruthenium-106 brachytherapy for choroidal melanoma without transpupillary thermotherapy: Similar efficacy with improved visual outcome. Eur J Cancer. 2016;68:106ā13.
Naseripour M, Jaberi R, Sedaghat A, Azma Z, Nojomi M, Falavarjani KG, et al. Ruthenium-106 brachytherapy for thick uveal melanoma: reappraisal of apex and base dose radiation and dose rate. J Contemp Brachytherapy. 2016;8:66ā73.
Wisely CE, Hadziahmetovic M, Reem RE, Hade EM, Nag S, Davidorf FH, et al. Long-term visual acuity outcomes in patients with uveal melanoma treated with 125I episcleral OSU-Nag plaque brachytherapy. Brachytherapy. 2016;15:12ā22.
Weber B, Paton K, Ma R, Pickles T. Outcomes of proton beam radiotherapy for large non-peripapillary choroidal and ciliary body melanoma at TRIUMF and the BC cancer agency. Ocul Oncol Pathol. 2015;2:29ā35.
Browne AW, Dandapani SV, Jennelle R, Stevanovic M, Lee TC, Murphree AL, et al. Outcomes of medium choroidal melanomas treated with ruthenium brachytherapy guided by three-dimensional pretreatment modeling. Brachytherapy. 2015;14:718ā25.
Fili M, Lundell G, Lundell M, Seregard S. High dose rate and low dose rate ruthenium brachytherapy for uveal melanoma. No association with ocular outcome. Br J Ophthalmol. 2014;98:1349ā54.
Jancar B, Budihna M, Drnovsek-Olup B, Andrejcic KN, Zupancic IB, Pahor D. Prognostic factors of choroidal melanoma in Slovenia, 1986-2008. Radio Oncol. 2016;50:104ā12.
Seibel I, Cordini D, Rehak M, Hager A, Riechardt AI, Bƶker A, et al. Local recurrence after primary proton beam therapy in uveal melanoma: risk factors, retreatment approaches, and outcome. Am J Ophthalmol. 2015;160:628ā36.
Sikuade MJ, Salvi S, Rundle PA, Errington DG, Kacperek A, Rennie IG. Outcomes of treatment with stereotactic radiosurgery or proton beam therapy for choroidal melanoma. Eye. 2015;29:1194ā8.
Tarmann L, Wackernagel W, Avian A, Mayer C, Schneider M, Winkler P, et al. Ruthenium-106 plaque brachytherapy for uveal melanoma. Br J Ophthalmol. 2015;99:1644ā9.
Takiar V, Voong KR, Gombos DS, Mourtada F, Rechner LA, Lawyer AA, et al. A choice of radionuclide: Comparative outcomes and toxicity of ruthenium-106 and iodine-125 in the definitive treatment of uveal melanoma. Pract Radiat Oncol. 2015;5:e169āe176.
Vonk DT, Kim Y, Javid C, Gordon JD, Stea B. Prescribing to tumor apex in episcleral plaque iodine-125 brachytherapy for medium-sized choroidal melanoma: a single-institutional retrospective review. Brachytherapy. 2015;14:726ā33.
Petrovic A, Bergin C, Schalenbourg A, Goitein G, Zografos L. Proton therapy for uveal melanoma in 43 juvenile patients: long-term results. Ophthalmology. 2014;121:898ā904.
Rahmi A, Mammar H, Thariat J, Angellier G, Herault J, Chauvel P, et al. Proton beam therapy for presumed and confirmed iris melanomas: a review of 36 cases. Graefes Arch Clin Exp Ophthalmol. 2014;252:1515ā21.
Badiyan SN, Rao RC, Apicelli AJ, Acharya S, Verma V, Garsa AA, et al. Outcomes of iodine-125 plaque brachytherapy for uveal melanoma with intraoperative ultrasonography and supplemental transpupillary thermotherapy. Int J Radiat Oncol Biol Phys. 2014;88:801ā5.
Barker CA, Francis JH, Cohen GN, Marr BP, Wolden SL, McCormick B, et al. (106)Ru plaque brachytherapy for uveal melanoma: factors associated with local tumor recurrence. Brachytherapy. 2014;13:584ā90.
Perez BA, Mettu P, Vajzovic L, Rivera D, Alkaissi A, Steffey BA, et al. Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes. Int J Radiat Oncol Biol Phys. 2014;89:127ā36.
Sagoo MS, Shields CL, Emrich J, Mashayekhi A, Komarnicky L, Shields JA. Plaque radiotherapy for juxtapapillary choroidal melanoma: treatment complications and visual outcomes in 650 consecutive cases. JAMA Ophthalmol. 2014;132:697ā702.
Salkola S, Heikkonen J, Eskelin S, KivelƤ T. Management of choroidal melanomas less than 10 mm in largest basal diameter with a 10-mm ruthenium plaque. Retina. 2014;34:2110ā20.
Sandinha MT, Kacperek A, Errington RD, Coupland SE, Damato B. Recurrence of iris melanoma after proton beam therapy. Br J Ophthalmol. 2014;98:484ā7.
Wagner A, Chen A, Cook T, Faber D, Winward K, Sause W. Outcomes and control rates for I-125 plaque brachytherapy for uveal melanoma: a community-based institutional experience. ISRN Ophthalmol. 2014;2014:950975.
Berry JL, Dandapani SV, Stevanovic M, Lee TC, Astrahan M, Murphree AL, et al. Outcomes of choroidal melanomas treated with eye physics: a 20-year review. JAMA Ophthalmol. 2013;131:1435ā42.
Caminal JM, Mejia K, Masuet-Aumatell C, Arias L, Piulats JM, Gutierrez C, et al. Endoresection versus iodine-125 plaque brachytherapy for the treatment of choroidal melanoma. Am J Ophthalmol. 2013;156:334ā42.e331.
Caujolle JP, Paoli V, Chamorey E, Maschi C, Baillif S, Herault J, et al. Local recurrence after uveal melanoma proton beam therapy: recurrence types and prognostic consequences. Int J Radiat Oncol Biol Phys. 2013;85:1218ā24.
Konstantinidis L, Roberts D, Errington RD, Kacperek A, Damato B. Whole anterior segment proton beam radiotherapy for diffuse iris melanoma. Br J Ophthalmol. 2013;97:471ā4.
Krema H, Heydarian M, Beiki-Ardakani A, Weisbrod D, Xu W, Laperriere NJ, et al. Dosimetric and late radiation toxicity comparison between iodine-125 brachytherapy and stereotactic radiation therapy for juxtapapillary choroidal melanoma. Int J Radiat Oncol Biol Phys. 2013;86:510ā5.
Marconi DG, de Castro DG, RebouƧas LM, Bernardes Gil GO, Fogaroli RC, Conte Maia MA, et al. Tumor control, eye preservation, and visual outcomes of ruthenium plaque brachytherapy for choroidal melanoma. Brachytherapy. 2013;12:235ā9.
Mishra KK, Daftari IK, Weinberg V, Cole T, Quivey JM, Castro JR, et al. Risk factors for neovascular glaucoma after proton beam therapy of uveal melanoma: a detailed analysis of tumor and dose-volume parameters. Int J Radiat Oncol Biol Phys. 2013;87:330ā336.
Murray TG, Markoe AM, Gold AS, Ehlies F, Bermudez E, Wildner A, et al. Long-term followup comparing two treatment dosing strategies of (125) I plaque radiotherapy in the management of small/medium posterior uveal melanoma. J Ophthalmol. 2013;2013:517032.
Quinlan-Davidson S, AlMahmoud T, Shenouda G, Evans M, Mansour M, Edelstein C, et al. Intraoperative sonographically assisted radioactive iodine 125 plaque brachytherapy for choroidal melanoma: visual acuity outcome. J Ultrasound Med. 2013;32:995ā1001.
Toyama S, Tsuji H, Mizoguchi N, Nomiya T, Kamada T, Tokumaru S, et al. Long-term results of carbon ion radiation therapy for locally advanced or unfavorably located choroidal melanoma: usefulness of CT-based 2-port orthogonal therapy for reducing the incidence of neovascular glaucoma. Int J Radiat Oncol Biol Phys. 2013;86:270ā6.
Desjardins L, Lumbroso-Le Rouic L, Levy-Gabriel C, Cassoux N, Dendale R, Mazal A, et al. Treatment of uveal melanoma by accelerated proton beam. Dev Ophthalmol. 2012;49:41ā57.
Finger PT, Chin KJ, Tena LB. A five-year study of slotted eye plaque radiation therapy for choroidal melanoma: near, touching, or surrounding the optic nerve. Ophthalmology. 2012;119:415ā22.
GarcĆa-Ćlvarez C, Saornil MA, LĆ³pez-Lara F, Almaraz A, MuƱoz MF, Frutos-Baraja J, et al. Episcleral brachytherapy for uveal melanoma: analysis of 136 cases. Clin Transl Oncol. 2012;14:350ā5.
Perri P, Fiorica F, DāAngelo S, Lamberti G, Parmeggiani F, Martini A, et al. Ruthenium-106 eye plaque brachytherapy in the conservative treatment of uveal melanoma: a mono-institutional experience. Eur Rev Med Pharm Sci. 2012;16:1919ā24.
Russo A, Laguardia M, Damato B. Eccentric ruthenium plaque radiotherapy of posterior choroidal melanoma. Graefes Arch Clin Exp Ophthalmol. 2012;250:1533ā40.
Tran E, Ma R, Paton K, Blackmore E, Pickles T. Outcomes of proton radiation therapy for peripapillary choroidal melanoma at the BC Cancer Agency. Int J Radiat Oncol Biol Phys. 2012;83:1425ā31.
Yarovoy AA, Magaramov DA, Bulgakova ES. The comparison of ruthenium brachytherapy and simultaneous transpupillary thermotherapy of choroidal melanoma with brachytherapy alone. Brachytherapy. 2012;11:224ā9.
Karlovits B, Trombetta MG, Verstraeten T, Johnson M, Wong M, Karlovits S. Local control and visual acuity following treatment of medium-sized ocular melanoma using a contact eye plaque: a single surgeon experience. Brachytherapy. 2011;10:228ā31.
Lane AM, Kim IK, Gragoudas ES. Proton irradiation for peripapillary and parapapillary melanomas. Arch Ophthalmol. 2011;129:1127ā30.
Leonard KL, Gagne NL, Mignano JE, Duker JS, Bannon EA, Rivard MJ. A 17-year retrospective study of institutional results for eye plaque brachytherapy of uveal melanoma using (125)I, (103)Pd, and (131)Cs and historical perspective. Brachytherapy. 2011;10:331ā9.
Macdonald EC, Cauchi P, Kemp EG. Proton beam therapy for the treatment of uveal melanoma in Scotland. Br J Ophthalmol. 2011;95:1691ā5.
Papageorgiou KI, Cohen VM, Bunce C, Kinsella M, Hungerford JL. Predicting local control of choroidal melanomas following 106Ru plaque brachytherapy. Br J Ophthalmol. 2011;95:166ā70.
Bianciotto C, Shields CL, Pirondini C, Mashayekhi A, Furuta M, Shields JA. Proliferative radiation retinopathy after plaque radiotherapy for uveal melanoma. Ophthalmology. 2010;117:1005ā12.
Caujolle JP, Mammar H, Chamorey E, Pinon F, Herault J, Gastaud P. Proton beam radiotherapy for uveal melanomas at nice teaching hospital: 16 yearsā experience. Int J Radiat Oncol Biol Phys. 2010;78:98ā103.
Daftari IK, Mishra KK, OāBrien JM, Tsai T, Park SS, Sheen M, et al. Fundus image fusion in EYEPLAN software: an evaluation of a novel technique for ocular melanoma radiation treatment planning. Med Phys. 2010;37:5199ā207.
GĆ¼ndĆ¼z K, Kurt RA, AkmeÅe HE, Kƶse K, UƧakhan-GĆ¼ndĆ¼z O. Ruthenium-106 plaque radiotherapy alone or in combination with transpupillary thermotherapy in the management of choroidal melanoma. Jpn J Ophthalmol. 2010;54:338ā43.
GĆ¼ndĆ¼z AK, Mirzayev I. Secondary endoresection for previously treated choroidal melanomas with a non-responsive course and persistent exudative retinal detachment. Int J Ophthalmol. 2022;15:276ā83.
Saconn PA, Gee CJ, Greven CM, McCoy TP, Ekstrand KE, Greven KM. Alternative dose for choroidal melanoma treated with an iodine-125 radioactive plaque: a single-institution retrospective study. Int J Radiat Oncol Biol Phys. 2010;78:844ā8.
Verschueren KM, Creutzberg CL, Schalij-Delfos NE, Ketelaars M, Klijsen FL, Haeseker BI, et al. Long-term outcomes of eye-conserving treatment with Ruthenium(106) brachytherapy for choroidal melanoma. Radiother Oncol. 2010;95:332ā8.
Aziz S, Taylor A, McConnachie A, Kacperek A, Kemp E. Proton beam radiotherapy in the management of uveal melanoma: clinical experience in Scotland. Clin Ophthalmol. 2009;3:49ā55.
Correa R, Pera J, GĆ³mez J, Polo A, GutiĆ©rrez C, Caminal JM, et al. (125)I episcleral plaque brachytherapy in the treatment of choroidal melanoma: a single-institution experience in Spain. Brachytherapy. 2009;8:290ā6.
Frenkel S, Hendler K, Peāer J. Uveal melanoma in Israel in the last two decades: characterization, treatment and prognosis. Isr Med Assoc J. 2009;11:280ā5.
Kaiserman N, Kaiserman I, Hendler K, Frenkel S, Peāer J. Ruthenium-106 plaque brachytherapy for thick posterior uveal melanomas. Br J Ophthalmol. 2009;93:1167ā71.
Mosci C, Mosci S, Barla A, Squarcia S, Chauvel P, Iborra N. Proton beam radiotherapy of uveal melanoma: Italian patients treated in Nice, France. Eur J Ophthalmol. 2009;19:654ā60.
Krohn J, Monge OR, Skorpen TN, MĆørk SJ, Dahl O. Posterior uveal melanoma treated with I-125 brachytherapy or primary enucleation. Eye. 2008;22:1398ā403.
Sagoo MS, Shields CL, Mashayekhi A, Freire J, Emrich J, Reiff J, et al. Plaque radiotherapy for juxtapapillary choroidal melanoma overhanging the optic disc in 141 consecutive patients. Arch Ophthalmol. 2008;126:1515ā22.
Mossbƶck G, Rauscher T, Winkler P, Kapp KS, Langmann G. Impact of dose rate on clinical course in uveal melanoma after brachytherapy with ruthenium-106. Strahlenther Onkol. 2007;183:571ā5.
Sagoo MS, Shields CL, Mashayekhi A, Freire J, Emrich J, Reiff J, et al. Plaque radiotherapy for choroidal melanoma encircling the optic disc (circumpapillary choroidal melanoma). Arch Ophthalmol. 2007;125:1202ā9.
Dendale R, Lumbroso-Le Rouic L, Noel G, Feuvret L, Levy C, Delacroix S, et al. Proton beam radiotherapy for uveal melanoma: results of Curie Institut-Orsay proton therapy center (ICPO). Int J Radiat Oncol Biol Phys. 2006;65:780ā7.
Isager P, Ehlers N, Urbak SF, Overgaard J. Visual outcome, local tumour control, and eye preservation after 106Ru/Rh brachytherapy for choroidal melanoma. Acta Oncol. 2006;45:285ā93.
Puusaari I, Damato B, KivelƤ T. Transscleral local resection versus iodine brachytherapy for uveal melanomas that are large because of tumour height. Graefes Arch Clin Exp Ophthalmol. 2007;245:522ā33.
Bergman L, Nilsson B, Lundell G, Lundell M, Seregard S. Ruthenium brachytherapy for uveal melanoma, 1979-2003: survival and functional outcomes in the Swedish population. Ophthalmology. 2005;112:834ā40.
Damato B, Patel I, Campbell IR, Mayles HM, Errington RD. Local tumor control after 106Ru brachytherapy of choroidal melanoma. Int J Radiat Oncol Biol Phys. 2005;63:385ā91.
Damato B, Kacperek A, Chopra M, Campbell IR, Errington RD. Proton beam radiotherapy of choroidal melanoma: the Liverpool-Clatterbridge experience. Int J Radiat Oncol Biol Phys. 2005;62:1405ā11.
Jensen AW, Petersen IA, Kline RW, Stafford SL, Schomberg PJ, Robertson DM. Radiation complications and tumor control after 125I plaque brachytherapy for ocular melanoma. Int J Radiat Oncol Biol Phys. 2005;63:101ā8.
Lotayef MM, Othman IS, Shelil AE, Kerima H. Ru106 brachytherapy for management of choroidal melanoma: do we need to adjust total dose according to the new NIST calibration measurement? J Egypt Natl Canc Inst. 2005;17:211ā7.
Stack R, Elder M, Abdelaal A, Hidajat R, Clemett R. New Zealand experience of I125 brachytherapy for choroidal melanoma. Clin Exp Ophthalmol. 2005;33:490ā4.
Egger E, Zografos L, Schalenbourg A, Beati D, Bƶhringer T, Chamot L, et al. Eye retention after proton beam radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys. 2003;55:867ā80.
Georgopoulos M, Zehetmayer M, Ruhswurm I, Toma-Bstaendig S, SĆ©gur-Eltz N, Sacu S, et al. Tumour regression of uveal melanoma after ruthenium-106 brachytherapy or stereotactic radiotherapy with gamma knife or linear accelerator. Ophthalmologica. 2003;217:315ā9.
Novak-Andrejcic K, Jancar B, Hawlina M. Echographic follow-up of malignant melanoma of the choroid after brachytherapy with 106Ru. Klin Monbl Augenheilkd. 2003;220:853ā60.
Gragoudas ES, Lane AM, Munzenrider J, Egan KM, Li W. Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma. Trans Am Ophthalmol Soc. 2002;100:43ā48.
Egger E, Schalenbourg A, Zografos L, Bercher L, Boehringer T, Chamot L, et al. Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma. Int J Radiat Oncol Biol Phys. 2001;51:138ā47.
Fuss M, Loredo LN, Blacharski PA, Grove RI, Slater JD. Proton radiation therapy for medium and large choroidal melanoma: preservation of the eye and its functionality. Int J Radiat Oncol Biol Phys. 2001;49:1053ā9.
Egan KM, Ryan LM, Gragoudas ES. Survival implications of enucleation after definitive radiotherapy for choroidal melanoma: an example of regression on time-dependent covariates. Arch Ophthalmol. 1998;116:366ā70.
Char DH, Kroll SM, Castro J. Long-term follow-up after uveal melanoma charged particle therapy. Trans Am Ophthalmol Soc. 1997;95:171ā87.
Summanen P, Immonen I, KivelƤ T, Tommila P, Heikkonen J, Tarkkanen A. Radiation related complications after ruthenium plaque radiotherapy of uveal melanoma. Br J Ophthalmol. 1996;80:732ā9.
Kleineidam M, Guthoff R, Bentzen SM. Rates of local control, metastasis, and overall survival in patients with posterior uveal melanomas treated with ruthenium-106 plaques. Radiother Oncol. 1993;28:148ā56.
Seddon JM, Gragoudas ES, Egan KM, Glynn RJ, Howard S, Fante RG, et al. Relative survival rates after alternative therapies for uveal melanoma. Ophthalmology. 1990;97:769ā77.
Lommatzsch PK. Results after beta-irradiation (106Ru/106Rh) of choroidal melanomas. Twenty yearsā experience. Am J Clin Oncol. 1987;10:146ā51.
Wang Z, Nabhan M, Schild SE, Stafford SL, Petersen IA, Foote RL, et al. Charged particle radiation therapy for uveal melanoma: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys. 2013;86:18ā26.
Hungerford JL. Current trends in the treatment of ocular melanoma by radiotherapy. Clin Exp Ophthalmol. 2003;31:8ā13.
Ophthalmic Oncology Task Force. Local recurrence significantly increases the risk of metastatic uveal melanoma. Ophthalmology. 2016;123:86ā91.
Buonanno F, Conson M, de Almeida Ribeiro C, Oliviero C, Itta F, Liuzzi R, et al. Local tumor control and treatment related toxicity after plaque brachytherapy for uveal melanoma: a systematic review and a data pooled analysis. Radiother Oncol. 2022;166:15ā25.
Mishra KK, Daftari IK. Proton therapy for the management of uveal melanoma and other ocular tumors. Chin Clin Oncol. 2016;5:50.
Schulz-Ertner D, JƤkel O, Schlegel W. Radiation therapy with charged particles. Semin Radiat Oncol. 2006;16:249ā59.
Mathis T, Cassoux N, Tardy M, Piperno S, Gastaud L, Dendale R, et al. [Management of uveal melanomas, guidelines for oncologists]. Bull Cancer. 2018;105:967ā80.
Daftari IK, Char DH, Verhey LJ, Castro JR, Petti PL, Meecham WJ, et al. Anterior segment sparing to reduce charged particle radiotherapy complications in uveal melanoma. Int J Radiat Oncol* Biol* Phys. 1997;39:997ā1010.
Seibel I, Riechardt AI, Heufelder J, Cordini D, Joussen AM. Adjuvant ab interno tumor treatment after proton beam irradiation. Am J Ophthalmol. 2017;178:94ā100.
Borenstein M, Hedges L, Higgins J, Rothstein H. Introduction to meta-analysis. Chichester, UK: John Wiley & Sons. Ltd. 2009.
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YHT, CAH and YBC were responsible for designing the review protocol, screening potentially eligible studies, and interpreting results. YHT and CAH were responsible for conducting the search, extracting and analyzing the data, updating reference lists and drafting the original article. YBC supervised and provided feedback on the report. All authors have read and agreed to the published version of the manuscript.
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Tseng, YH., Hsu, CA. & Chou, YB. Comparing efficacy of charged-particle therapy with brachytherapy in treatment of uveal melanoma. Eye (2024). https://doi.org/10.1038/s41433-024-03035-y
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DOI: https://doi.org/10.1038/s41433-024-03035-y