Functional presentations—sometimes called perplexing presentations, or medically unexplained symptoms—include a wide range of physical symptoms which are not fully explained by clinical findings [1]. In children and young people (CYP) with functional symptoms there may be problems in the family or at school, pre-existing physical illness or psychological disorders such as anxiety, low-mood or behavioural difficulties [2, 3].
Yet, little is known about psychiatric co-morbidity in CYP presenting with functional visual symptoms (FVS), a presentation common to eye clinics [4]. In CYP, FVS is generally considered to resolve spontaneously, and treatment typically includes reassurance. Children with other functional symptoms (e.g. medically unexplained headache or seizures) may benefit from psychological interventions, but it not currently clear whether CYP with FVS may also benefit [1]. We identified 85 CYP aged 5–16 years (54 females; median age 9 years) with FVS presenting to Moorfields Eye Hospital during the calendar year of 2015. In 2016/2017, following NHS-HRA approval (16/LO/0837), we reviewed the case notes. We invited all families for a face-to-face interview and assessment of the CYP’s mental health. 6 families consented to take part (Fig. 1). Five families completed the online Development and Wellbeing Assessment (DAWBA [5]) questionnaire (age 7–13 years, 3 girls, Table 1), a validated computerised clinical assessment for mental health problems in children. Four also attended a semi-structured clinical interview with a child and adolescent psychiatrist (IH) and clinical psychologist (AC).
FVS had included intermittent blurred vision, double vision and difficulties with reading. In four children, the symptoms had resolved; one still had intermittent blurred vision. The DAWBA did not identify any current emotional, behavioural, social or educational difficulties. Two reported other functional symptoms (e.g. abdominal pain, nausea or headaches). Interviews indicated that in all cases there was a potential identifiable initial trigger of FVS, including difficulties at school and bereavements, on a background of parents describing their child as having a sensitive personality.
The participation rate was lower than anticipated (5/41, 12.2%). However, case note review showed that 84 of the originally identified 85 CYP (99%) had been discharged after their first episode of FVS or were under follow-up for treatable eye conditions such as strabismus (Fig. 1), with a median number of consultations of 2 (interquartile range, 1–3), and median follow-up of 35 days (IQR 0–118). Four CYP (5%) had re-attended with another episode of FVS, after a median interval of 265 days (IQR 203–332) after discharge. In all four, the subsequent episode resolved with re-assurance. One 14-year old girl was still under follow-up for ongoing subjective reduction in vision, 30 months after initial presentation.
In summary, none of the children who underwent detailed mental health assessment met criteria for a psychiatric disorder, and in all of them, the FVS had resolved. The spontaneous remission and absence of psychiatric problems may have contributed to the apparent reluctance of families to participate in this study. Our finding of a high rate of discharge from clinics and low rate of re-attendances may confirm that in most children, FVS are at the milder end of the spectrum of functional symptoms, and that the re-assurance ophthalmologists provide is sufficient.
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Acknowledgements
The study was funded by Moorfields Eye Charity (ST 15 07K). ADN and MD are employed by the National Institute for Health Research (NIHR) Moorfields Biomedical Research Centre, and as such the work was supported by the NIHR. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The research was supported by the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by A Coughtrey and M Daniel. The first draft of the manuscript was written by A Dahlmann-Noor and all authors commented on the manuscript and developed the final version.
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Coughtrey, A.E., Daniel, M.C., Dahlmann-Noor, A. et al. Functional visual symptoms in children and young people: mental health profiles and case review. Eye 36, 1111–1112 (2022). https://doi.org/10.1038/s41433-021-01640-9
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DOI: https://doi.org/10.1038/s41433-021-01640-9