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Effect of coffee, tea and alcohol intake on circulating inflammatory cytokines: a two sample-Mendelian randomization study

European Journal of Clinical Nutrition (2024)Cite this article

Subjects

Abstract

Background

Despite the abundance of research examining the effects of coffee, tea, and alcohol on inflammatory diseases, there is a notable absence of conclusive evidence regarding their direct causal influence on circulating inflammatory cytokines. Previous studies have primarily concentrated on established cytokines, neglecting the potential impact of beverage consumption on lesser-studied but equally important cytokines.

Methods

Information regarding the consumption of coffee, tea, and alcohol was collected from the UK Biobank, with sample sizes of 428,860, 447,485, and 462,346 individuals, respectively. Data on 41 inflammatory cytokines were obtained from summary statistics of 8293 healthy participants from Finnish cohorts.

Results

The consumption of coffee was found to be potentially associated with decreased levels of Macrophage colony-stimulating factor (β = −0.57, 95% CI −1.06 ~ −0.08; p = 0.022) and Stem cell growth factor beta (β = −0.64, 95% CI −1.16 ~ −0.12; p = 0.016), as well as an increase in TNF-related apoptosis-inducing ligand (β = 0.43, 95% CI 0.06 ~ 0.8; p = 0.023) levels. Conversely, tea intake was potentially correlated with a reduction in Interleukin-8 (β = −0.45, 95% CI −0.9 ~ 0; p = 0.045) levels. Moreover, our results indicated an association between alcohol consumption and decreased levels of Regulated on Activation, Normal T Cell Expressed and Secreted (β = −0.24, 95% CI −0.48 ~ 0; p = 0.047), as well as an increase in Stem cell factor (β = 0.17, 95% CI 0.02 ~ 0.31; p = 0.023) and Stromal cell-derived factor-1 alpha (β = 0.20, 95% CI 0.04 ~ 0.36; p = 0.013).

Conclusion

Revealing the interactions between beverage consumption and various inflammatory cytokines may lead to the discovery of novel therapeutic targets, thereby facilitating dietary interventions to complement clinical disease treatments.

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Fig. 1
Fig. 2
Fig. 3: Scatter plot of nominal significant estimates of coffee, tea and alcohol intake on inflammatory cytokines based on genetic predictions.
Fig. 4

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Data availability

The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.

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Acknowledgements

This work was supported by the School of Food Science and technology, Jiangnan University.

Funding

The work was supported by Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Future Food Technology Innovation Center (bm2020023) and Natural Science Foundation of China (32172136).

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Reacher Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, No. 1800, Lihu Road, Wuxi, 214122, Jiangsu, China

    Yuan He, Shuang Zhu, Yu Zhang, Yuanfa Liu & Yong-Jiang Xu

  2. Department of Food Technology, Faculty of Food Science and Technology, University Putra Malaysia, Seri Kembangan, Selangor, 410500, Malaysia

    Chin Ping Tan

  3. Cancer Center, Department of Medical Oncology, Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China

    Jianbin Zhang

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Yuan He, Yong-Jiang Xu and Yuan-Fa Liu: Conceived and designed the experiments; Yuan He and Shuang Zhu: Performed and analyzed the experiments. Yuan He, Yu Zhang and Shuang Zhu: Collecting data; Yuan He, Jian-Bin Zhang, Yong-Jiang Xu and Chin Ping Tan: Wrote and revised the manuscript. All authors read and approved the final manuscript.

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He, Y., Zhu, S., Zhang, Y. et al. Effect of coffee, tea and alcohol intake on circulating inflammatory cytokines: a two sample-Mendelian randomization study. Eur J Clin Nutr (2024). https://doi.org/10.1038/s41430-024-01438-4

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