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Metabolism and Metabolomics

Vitamin C status and its change in relation to glucose-lipid metabolism in overweight and obesity patients following laparoscopic sleeve gastrectomy

European Journal of Clinical Nutrition volume 76, pages 1387–1392 (2022)Cite this article

Subjects

Abstract

Objectives

Aimed to demonstrate the association of VC and metabolism in the obesity or overweight and determine VC changes after laparoscopic sleeve gastrectomy (LSG).

Methods

A total of 253 overweight or people with obesity were recruited, including 61 with LSG. They were divided into group A (VC < 34 ug/ml) and group B (VC ≥ 34 ug/ml). Glucose-lipid metabolic parameters were compared, and VC status before and 6 and 12 months after LSG were measured.

Results

(1) Body weight, body mass index (BMI), neck circumference (NC), waist circumference (WC), hip circumference (HC), waist-to-hip ratio, heart rate (HR), diastolic systolic pressure (DBP), 2-hour postprandial glucose (2h-BG), fasting insulin (FINS), 2-hour postprandial insulin (2h-INS), glycosylated hemoglobin (HBG), homeostasis model of insulin resistance (HOMA-IR), total cholesterol (TCH), triglyceride (TG) and free fatty acid (FFA) were higher while high-density lipoprotein (HDL-C) was lower in group A than group B (p < 0.05). (2) VC was negatively correlated with body weight, BMI, NC, WC and HC, HR, SBP, DBP, and 2h-BG, FINS, 2h-INS, HGB, HOMA-IR, TG and FFA, while positively with HDL-C (p < 0.05). (3) Patients with obesity or hypertriglyceridemia or low HDL-C had lower VC than corresponding group. (p < 0.05). (4) Logistic regression analysis showed that VC was the independent risk factor of hypertriglyceridemia, obesity and low HDL-C 5) VC concentrations were slightly increased in 6 months after LSG, and unchanged in 12 months after LSG.

Conclusion

VC was closely associated with glucose-lipid metabolism, and may play a protective role in metabolic disorders. LSG would not worsen the VC status or deficiency.

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Fig. 1: The level of VC in different metabolic groups.
Fig. 2: The level of VC before and 6 or 12 months after LSG.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors are grateful to all the participants of this study for their contributions. The research was supported by the Climbing Talent Program of Shanghai Tenth People’s Hospital (2021SYPDRC047)

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  1. These authors contributed equally: Jiajing Yin and Lei Du.

Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China

    Jiajing Yin, Lei Du, Chunjun Sheng, Hui You, Xingchun Wang & Shen Qu

  2. Shanghai Center of Thyroid Diseases, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China

    Jiajing Yin, Chunjun Sheng, Hui You, Xingchun Wang & Shen Qu

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JY was responsible for conducting the research and writing the protocol and report. LD conducted the analyses of the data. CS and HY collected the data. XW and SQ designed the research protocol.

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Correspondence to Xingchun Wang or Shen Qu.

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Yin, J., Du, L., Sheng, C. et al. Vitamin C status and its change in relation to glucose-lipid metabolism in overweight and obesity patients following laparoscopic sleeve gastrectomy. Eur J Clin Nutr 76, 1387–1392 (2022). https://doi.org/10.1038/s41430-022-01134-1

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