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Okichromanone, a new antiviral chromanone from a marine-derived Microbispora

The Journal of Antibiotics volume 77, pages 389–392 (2024)Cite this article

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Abstract

Okichromanone (1), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora, along with known 1-hydroxyphenazine (2). Compound 1 was elucidated to exist as a mixture of two isomeric structures (1a and 1b) at a ratio of nearly 3:2. Compounds 1 and 2 showed anti HSV-I activity with IC50 values 40 and 86 μM, respectively, and anti HSV-II activity with IC50 values 59 and 123 μM, respectively.

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Authors and Affiliations

  1. Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

    Marwa Elsbaey

  2. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan

    Marwa Elsbaey, Naoya Oku & Yasuhiro Igarashi

  3. Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa, 903-0213, Japan

    Takahiro Jomori & Junichi Tanaka

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  1. Marwa Elsbaey
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Correspondence to Marwa Elsbaey.

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Elsbaey, M., Jomori, T., Tanaka, J. et al. Okichromanone, a new antiviral chromanone from a marine-derived Microbispora. J Antibiot 77, 389–392 (2024). https://doi.org/10.1038/s41429-024-00718-2

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  • DOI: https://doi.org/10.1038/s41429-024-00718-2

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