Abstract
Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.
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Acknowledgements
We are grateful to Distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support and valuable guidance and suggestions. We thank Dr. K. Nagai and Ms. N. Sato (School of Pharmacy, Kitasato University) for various instrumental analyses. This study was also partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from the Japan Agency for Medical Research & Development (AMED) under Grant Number JP21am0101096 (Phase I) and JP22ama121035 (Phase II) and Ichimura Foundation for New Technology. This study was also funded by JSPS KAKENHI (20K07106 and 23H04887).
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Kimura, Si., Watanabe, Y., Mikasa, Y. et al. Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058. J Antibiot 77, 206–213 (2024). https://doi.org/10.1038/s41429-023-00699-8
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DOI: https://doi.org/10.1038/s41429-023-00699-8