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Mollicellins S-U, three new depsidones from Chaetomium brasiliense SD-596 with anti-MRSA activities

The Journal of Antibiotics volume 74, pages 317–323 (2021)Cite this article

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Abstract

Fungi are important resources for drug development, as they have a diversity of genes, that can produce novel secondary metabolites with effective bioactivities. Here, five depsidone-based analogs were isolated from the rice media of Chaetomium brasiliense SD-596. Their structures were elucidated using NMR and mass spectrometry analysis. Five compounds, including three new depsidone analogs, mollicellin S (1), mollicellin T (2), and mollicellin U (3), and two known compounds, mollicellin D (4) and mollicellin H (5), exhibited significant inhibition against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA), with MIC values ranging from 6.25 to 12.5 μg ml−1. Herein, we identified the predicted plausible biosynthetic cluster of the compounds and discussed the structure-activity relationship. Finally, we found that the introduction of aldehyde and methoxyl groups provide marked improvement for the inhibition against MRSA.

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Acknowledgements

We gratefully acknowledge the financial support of the National Key R&D Program of China (Nos. 2017YFF0209900, 2017YFF0209904, 2017YFF0209902), National Natural Science Foundation of China (31770024), Qilu University of Technology (Shandong Academy of Sciences) International Cooperation Program (2019GHPY07), the Taishan Scholar Project from Shandong Province to Lixin Zhang, Xuekui Xia, Qilu University of Technology (Shandong Academy of Sciences) Joint Fund for Young Doctors (2017BSH2016), Science, Education and Industry Integration Innovation Pilot Project of Qilu University of Technology (Shandong Academy of Sciences) (2020KJC-ZD08).

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  1. These authors contributed equally: Peipei Zhao, Meng Yang

Authors and Affiliations

  1. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China

    Peipei Zhao, Meng Yang, Bo Zhao, Hong Wang, Hairong Liu, Xinzhu Wang, Jun Qi, Xin Yin, Lumin Yu, Yiwei Meng, Zhipu Li, Lixin Zhang & Xuekui Xia

  2. East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

    Guoliang Zhu & Lixin Zhang

  3. Shandong Normal University, Jinan, 250014, China

    Hong Wang

  4. Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China

    Xinzhu Wang

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  1. Peipei Zhao
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Correspondence to Lixin Zhang or Xuekui Xia.

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Zhao, P., Yang, M., Zhu, G. et al. Mollicellins S-U, three new depsidones from Chaetomium brasiliense SD-596 with anti-MRSA activities. J Antibiot 74, 317–323 (2021). https://doi.org/10.1038/s41429-020-00398-8

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