Abstract
Three undescribed chromanones (1–3) and two known chromanones (4 and 5) were isolated from the culture of endophytic fungus Phomopsis CGMCC No. 5416 from the stems of Achyranthes bidentata. Their structures were determined by spectroscopic analysis. Compounds 1 and 2 showed inhibitory activities against HIV-1 with IC50 values of 20.4 and 32.5 μg ml−1, respectively. Compounds 1–3 displayed moderate cytotoxicity with CC50 values of 36.5–79.3 μg ml−1 against A549, MDA-MB-231, and PANC-1 cell lines. Moreover, compound 3 can induce the early apoptosis of PANC-1 cancer cells with the apoptosis rate of 10.52%.
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Acknowledgements
The work was supported in part by grants from the National Natural Science Foundation of China (No. 81773616), the Shanghai Outstanding Academic Leaders Plan of Shanghai Municipal Science and Technology (17XD1423200), and the Shanghai Natural Science Foundation (16ZR1435400), the National S&T Major Special Project on Major New Drug Innovation (2012ZX09301-002-004).
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Yang, Z., Wu, K., Xu, Y. et al. Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC No. 5416. J Antibiot 73, 194–199 (2020). https://doi.org/10.1038/s41429-019-0270-0
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DOI: https://doi.org/10.1038/s41429-019-0270-0
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