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Warm up, cool down, and tearing apart in NK cell memory

Cellular & Molecular Immunology volume 15, pages 1095–1097 (2018)Cite this article

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“Memories warm you up from the inside. But they also tear you apart.” ― Haruki Murakami, Kafka on the Shore.

“Memories warm you up from the inside. But they also tear you apart.” ― Haruki Murakami, Kafka on the Shore.

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References

  1. Butz, E. A. & Bevan, M. J. Massive expansion of antigen-specific CD8+T cells during an acute virus infection. Immunity 8, 167–175 (1998).

    Article  CAS  Google Scholar 

  2. Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177–187 (1998).

    Article  CAS  Google Scholar 

  3. Williams, M. A. & Bevan, M. J. Effector and memory CTL differentiation. Annu. Rev. Immunol. 25, 171–192 (2007).

    Article  CAS  Google Scholar 

  4. Netea, M. G. et al. Trained immunity: a program of innate immune memory in health and disease. Science 352, aaf1098 (2016).

    Article  Google Scholar 

  5. Saeed, S. et al. Epigenetic programming of monocyteto- macrophage differentiation and trained innate immunity. Science 345, 1251086 (2014). 2014.

    Article  Google Scholar 

  6. Sun, J. C. & Lanier, L. L. NK cell development, homeostasis and function: parallels with CD8+ T cells. Nat. Rev. Immunol. 11, 645–657 (2011).

    Article  CAS  Google Scholar 

  7. Guillerey, C., Huntington, N. D. & Smyth, M. J. Targeting natural killer cells in cancer immunotherapy. Nat. Immunol. 17, 1025–1036 (2016).

    Article  CAS  Google Scholar 

  8. Brandstadter, J. D. & Yang, Y. Natural killer cell responses to viral infection. J. Innate Immun. 3, 274–279 (2011).

    Article  CAS  Google Scholar 

  9. Liu, S. et al. Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection. Cell Mol. Immunol. 13, 700–708 (2016).

    Article  CAS  Google Scholar 

  10. Sun, C., Sun, H., Zhang, C. & Tian, Z. NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma. Cell Mol. Immunol. 12, 292–302 (2015).

    Article  CAS  Google Scholar 

  11. Zingoni, A. et al. Crosstalk between activated human NK cells and CD4+T cells via OX40-OX40 ligand interactions. J. Immunol. 173, 3716–3724 (2004).

    Article  CAS  Google Scholar 

  12. Zingoni, A., Ardolino, M., Santoni, A. & Cerboni, C. NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses. Front. Immunol. 3, 408 (2012).

    PubMed  Google Scholar 

  13. Moretta, A. The dialogue between human natural killer cells and dendritic cells. Curr. Opin. Immunol. 17, 306–311 (2005).

    Article  CAS  Google Scholar 

  14. Crouse, J., Xu, H. C., Lang, P. A. & Oxenius, A. NK cells regulating T cell responses: mechanisms and outcome. Trends Immunol. 36, 49–58 (2015).

    Article  CAS  Google Scholar 

  15. Cerwenka, A. & Lanier, L. L. Natural killer cell memory in infection, inflammation and cancer. Nat. Rev. Immunol. 16, 112–123 (2016).

    Article  CAS  Google Scholar 

  16. Sun, J. C., Beilke, J. N. & Lanier, L. L. Adaptive immune features of natural killer cells. Nature 457, 557–561 (2009).

    Article  CAS  Google Scholar 

  17. Peng, H. & Tian, Z. Natural killer cell memory: progress and implications. Front. Immunol. 8, 1143 (2017).

    Article  Google Scholar 

  18. Lau, C. M. et al. Epigenetic control of innate and adaptive immune memory. Nat. Immunol. 19, 963–972 (2018).

    Article  CAS  Google Scholar 

  19. Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y. & Greenleaf, W. J. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat. Methods 10, 1213–1218 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Graduate Institute of Medical Sciences, China Medical University, Taichung, Taiwan, China

    Lawrence Shih-Hsin Wu

  2. Department of Pediatrics, Center for Allergy and Clinical Immunology Research, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, China

    Jiu-Yao Wang

Authors
  1. Lawrence Shih-Hsin Wu
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Correspondence to Lawrence Shih-Hsin Wu or Jiu-Yao Wang.

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Wu, L.SH., Wang, JY. Warm up, cool down, and tearing apart in NK cell memory. Cell Mol Immunol 15, 1095–1097 (2018). https://doi.org/10.1038/s41423-018-0188-7

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