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Reply to ‘Comment on ‘BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses’’

British Journal of Cancer volume 118, page 1154 (2018)Cite this article

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We thank Sauerbrei and Haeussler1 for their interest in our paper2 and their methodological comments. Our aim was to undertake these analyses and draw some conclusions from the available literature regarding the prognostic significance of BAG-1 in breast cancer, given multiple studies. We felt that this was important, particularly since BAG-1 is already included in multi-gene assays widely used as part of routine clinical practice and due to ongoing investigation into the possibility of inhibition of BAG-1 function as a potential therapeutic strategy. We did not use the supplementary information provided within the REMARK Explanation and Elaboration paper.3 We provided our interpretation whether details within the REMARK checklist were included in the papers and, as we highlighted, the literature reviewed was heterogeneous and with a range in study quality. We believe our conclusions were drawn with appropriate caveats to highlight this.

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References

  1. Sauerbrei W, Haeussler T. Comment on ‘BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses’. Br. J. Cancer https://doi.org/10.1038/s41416-018-0023-z (2018).

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  2. Papadakis, E. S. et al. BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses. Br. J. Cancer 116, 1585–1594, https://doi.org/10.1038/bjc.2017.130 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Altman, D. G., McShane, L. M., Sauerbrei, W. & Taube, S. E. Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration. BMC Med. 10, 51 (2012).

    Article  Google Scholar 

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Authors and Affiliations

  1. Cancer Research UK Centre Cancer Sciences Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK

    E. S. Papadakis, T. Reeves, N. H. Robson, G. Packham & R. I. Cutress

  2. Southampton Clinical Trials Unit, University of Southampton, Southampton, SO17 1BJ, UK

    T. Maishman

  3. University Hospital Southampton, University of Southampton Faculty of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK

    R. I. Cutress

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  1. E. S. Papadakis
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  2. T. Reeves
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  3. N. H. Robson
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  4. T. Maishman
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  5. G. Packham
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  6. R. I. Cutress
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Corresponding author

Correspondence to T. Reeves.

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The authors declare no competing interests.

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Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International licence (CC BY 4.0).

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Papadakis, E.S., Reeves, T., Robson, N.H. et al. Reply to ‘Comment on ‘BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses’’. Br J Cancer 118, 1154 (2018). https://doi.org/10.1038/s41416-018-0032-y

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