Abstract
This study investigates the interaction between endothelial activation, indirectly measured using EASIX, and the probability of presenting cardiac adverse events (CAE) during the first year after allo-HCT. The 437 consecutive adults undergoing PB allo-HCT from 2012 and 2021 were included. EASIX was retrospectively calculated before and during the first 6 months after allo-HCT and transformed to log2-base to conduct the statistical analysis. The median age was 53, 46 (10.5%) patients had previous history of cardiac disease, MAC allo-HCTs were performed in 186 (42.6%) patients, and PTCY was administered in 242 (55.5%). The 1-year incidence of CAE was 12.6% (n = 55). The most prevalent cardiac events were heart failure and arrhythmias, 32.7% and 23.6% respectively, and the day +100 mortality rate of these patients was 40.5%. During the first 6 months after allo-HCT, EASIX trends were significantly higher in patients who developed CAE. Regression analyses confirmed that higher log2-EASIX values were predictors for higher risk for CAE during the first year after allo-HCT. This analysis identifies a significant association between higher endothelial activation, indirectly measured using EASIX, and higher risk for cardiac toxicity diagnosed during the first year after allo-HCT and extends the applicability of EASIX for identifying patients at risk for CAE.
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Acknowledgements
We thank our patients and the nursing and support staff in the Hematopoietic Cell Transplant Program and the Cardiology Department at Hospital Clinic de Barcelona.
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MQS designed the study. CTR collected the data. MQS and CTR analyzed and interpreted the results and wrote the paper. EC, EC and MDR provided a valuable support into the interpretation of the results and statement of the conclusions. LGRL, AP, MSL, PC, JM, MTS, JC, ML, LR, JE, AUI, FFA, CM, EC, MDR and MR provided valuable input into the study and reviewed and approved the manuscript.
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Tolosa-Ridao, C., Cascos, E., Rodríguez-Lobato, L.G. et al. EASIX and cardiac adverse events after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant (2024). https://doi.org/10.1038/s41409-024-02270-x
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DOI: https://doi.org/10.1038/s41409-024-02270-x