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Quantifying skin cancer risk following allogeneic haematopoietic cell transplant in Queensland, Australia

Bone Marrow Transplantation volume 59, pages 144–146 (2024)Cite this article

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Fig. 1: Skin cancer-free survival.

Data availability

The datasets generated and analysed during the current study are not publicly available as these represent patient registries; however, further information is available from the corresponding author on reasonable request.

References

  1. Scott JF, Brough KR, Grigoryan KV, Muzic JG, Kim GY, Conic RRZ, et al. Risk factors for keratinocyte carcinoma in recipients of allogeneic hematopoietic cell transplants. JAMA Dermatol. 2020;156:631–9.

    Article  PubMed  Google Scholar 

  2. Curtis RE, Metayer C, Rizzo JD, Socié G, Sobocinski KA, Flowers MED, et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood. 2005;105:3802–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rizzo JD, Curtis RE, Socié G, Sobocinski KA, Gilbert E, Landgren O, et al. Solid cancers after allogeneic hematopoietic cell transplantation. Blood. 2009;113:1175–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wu PA, Stern RS, Huang V, Liu KX, Chen C, Tzachanis D, et al. Reduced-intensity conditioning regimens, prior chronic lymphocytic leukemia, and graft-versus-host disease are associated with higher rates of skin cancer after allogeneic hematopoietic stem cell transplantation. J Invest Dermatol. 2019;139:591–9.

    Article  CAS  PubMed  Google Scholar 

  5. DePry JL, Vyas R, Lazarus HM, Caimi PF, Gerstenblith MR, Bordeaux JS. Cutaneous malignant neoplasms in hematopoietic cell transplant recipients: a systematic review. JAMA Dermatol. 2015;151:775–82.

    Article  PubMed  Google Scholar 

  6. Herr MM, Curtis RE, Tucker MA, Tecca HR, Engels EA, Cahoon EK, et al. Risk factors for the development of cutaneous melanoma after allogeneic hematopoietic cell transplantation. J Am Acad Dermatol. 2020;83:762–72.

    Article  CAS  PubMed  Google Scholar 

  7. Wojenski DJ, Bartoo GT, Merten JA, Dierkhising RA, Barajas MR, el-Azhary RA, et al. Voriconazole exposure and the risk of cutaneous squamous cell carcinoma in allogeneic hematopoietic stem cell transplant patients. Transpl Infect Dis. 2015;17:250–8.

    Article  CAS  PubMed  Google Scholar 

  8. Whiteman DC, Thompson BS, Thrift AP, Hughes M-C, Muranushi C, Neale RE, et al. A model to predict the risk of keratinocyte carcinomas. J Invest Dermatol. 2016;136:1247–54.

    Article  CAS  PubMed  Google Scholar 

  9. Pandeya N, Olsen CM, Whiteman DC. The incidence and multiplicity rates of keratinocyte cancers in Australia. Med J Aust. 2017;207:339–43.

    Article  PubMed  Google Scholar 

  10. Olsen CM, Green AC, Neale RE, Webb PM, Cicero RA, Jackman LM, et al. Cohort profile: the QSkin Sun and Health Study. Int J Epidemiol. 2012;41:929–i.

    Article  PubMed  Google Scholar 

  11. Allen NC, Martin AJ, Snaidr VA, Eggins R, Chong AH, Fernandéz-Peñas P, et al. Nicotinamide for skin-cancer chemoprevention in transplant recipients. N Engl J Med. 2023;388:804–12.

    Article  CAS  PubMed  Google Scholar 

  12. Biswas NDJ, Teare H, Robertson I. Bone marrow transplant recipients and their compliance with sun-protection measures in Queensland, Australia. J Dermatol. 2020;47:430–4.

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors wish to acknowledge all patients whose data contributed to this study. This study was approved by the Metro North Human Research and Ethics Committee. The QSkin Study was approved by the Human Research Ethics Committee at the QIMR Berghofer Medical Research Institute (P1309, P2034).

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Authors and Affiliations

  1. Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women’s Hospital, Herston, QLD, Australia

    Philip Wong, Yin Yuan, Jason Butler, Cameron Curley, Simon Durrant, Andrea Henden,  James Morton, Elango Subramoniapillai, Caroline Stewart, Siok-Keen Tey, Glen A. Kennedy & Ashleigh P. Scott

  2. Faculty of Medicine, The University of Queensland, St Lucia, QLD, Australia

    Philip Wong, David C. Whiteman, Catherine M. Olsen, Andrea Henden & Ashleigh P. Scott

  3. Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia

    David C. Whiteman & Catherine M. Olsen

  4. Translational Cancer Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia

    Andrea Henden & Siok-Keen Tey

Authors
  1. Philip Wong
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  2. David C. Whiteman
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  3. Catherine M. Olsen
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  11. Caroline Stewart
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  13. Glen A. Kennedy
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  14. Ashleigh P. Scott
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Contributions

Study concept and design by APS. Retrospective HCT data collection by PW, YY and APS. DCW and CMO provided QSkin summary data and epidemiologic expertise. Statistical analysis by JB, S-KT and APS. All authors aside from DCW and CMO contributed directly to HCT patient care and primary data collection. PW and APS wrote the manuscript, and all authors contributed to the final manuscript.

Corresponding author

Correspondence to Ashleigh P. Scott.

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Competing interests

DCW is supported by a Research Fellowship [APP1155413] from the National Health and Medical Research Council of Australia (NHMRC). The QSkin Study has been supported by NHMRC grants APP1185416, APP1073898, APP552429, APP1063061. The authors declare no competing interests.

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Wong, P., Whiteman, D.C., Olsen, C.M. et al. Quantifying skin cancer risk following allogeneic haematopoietic cell transplant in Queensland, Australia. Bone Marrow Transplant 59, 144–146 (2024). https://doi.org/10.1038/s41409-023-02138-6

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  • DOI: https://doi.org/10.1038/s41409-023-02138-6

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