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MDT perspective: intraductal carcinoma of the prostate: implication for diagnosis and treatment

Prostate Cancer and Prostatic Diseases (2024)Cite this article

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Zhao et al. took the initiative of conducting the direct comparison of intraductal carcinoma of the prostate (IDC-P) and adenocarcinoma, by manually dissecting IDC-P from adenocarcinoma, followed by IHC validation, WES, RNA-seq and methylation sequencing [1]. It showed many interesting and new findings of IDC-P which are possibly underscored when previous researchers are using tumor mixtures as their IDC-P-containing model. Many of the findings here can help to explain the demonstrated aggressiveness of IDC-P and its worse responses to standard therapy. Certain results such as the enhanced cellular proliferation and intratumorally androgen biosynthesis can potentially enlighten future targeted therapies in this group of patients.

The study not only highlights IDC-P’s unique characteristics but also emphasizes the importance of nuanced investigations in prostate cancer. Precision medicine requires a relentless commitment to understanding subtypes like IDC-P, ensuring targeted interventions that consider the specific molecular intricacies of each patient’s cancer journey.

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Authors and Affiliations

  1. Department of Urology, West China Hospital, Sichuan University, Chengdu, China

    Hao Zeng

  2. Department of Urology, University of California, San Francisco, California, USA

    Sha Zhu

  3. Center for Translational Medicine, Second Military Medical University (Naval Medical University), Shanghai, 200433, China

    Jing Li

  4. Department of Pathology, West China Hospital, Sichuan University, Chengdu, China

    Ni Chen

  5. Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

    Yao Zhu

  6. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Yao Zhu

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  1. Hao Zeng
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  2. Sha Zhu
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  3. Jing Li
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Contributions

YZ, HZ, SZ, JL, and NC both contributed to the drafting and final approval of this manuscript.

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Correspondence to Yao Zhu.

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The authors declare no competing interests.

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Zeng, H., Zhu, S., Li, J. et al. MDT perspective: intraductal carcinoma of the prostate: implication for diagnosis and treatment. Prostate Cancer Prostatic Dis (2024). https://doi.org/10.1038/s41391-024-00818-y

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  • DOI: https://doi.org/10.1038/s41391-024-00818-y

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