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Myelodysplastic syndrome

Prognostic implication of appendicular skeleton bone marrow abnormalities detected using low-dose multidetector computed tomography in patients with myelodysplastic syndrome

Leukemia volume 32, pages 2069–2073 (2018)Cite this article

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Myelodysplastic syndrome (MDS) encompasses a series of heterogeneous hematologic conditions characterized by cytopenia, ineffective hematopoiesis, and an increased risk of developing acute myeloid leukemia (AML) [1]. A number of prognostic systems have been developed and validated in patients with MDS [2,3,4]. Among these, the Revised International Prognostic Scoring System (R-IPSS) integrates the number of known clinical features and stratifies the prognosis of MDS patients more precisely [5]. However, these prognostic systems are exclusively based on various clinical and demographic information derived mainly from the hematologic data of peripheral blood and bone marrow, as well as cytogenetic analyses.

Low-dose whole-body multidetector computed tomography (MDCT) is a useful modality for depicting bone marrow medullary and lytic bone lesions in patients with multiple myeloma (MM) [6,7,8]. We previously reported the prognostic role of abnormal medullary lesion of appendicular skeletons (AS) in patients with MM and related diseases using the MDCT [8]. Here, we examined the medullary abnormality in AS among patients with MDS and analyzed its relationship with the clinical parameters, subsequent development of leukemic transformation, and survival.

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Acknowledgements

We thank Katushige Kawamukai, Mituhisa Kato, Yusuke Akita, Hideto Hatakeyama, Kazuya Tomobe, and Shinya Koide for establishing the computed tomography protocol and performing image acquisition. We also thank Editage (www.editage.jp) for English language editing.

Author contributions

YA collected data, performed statistical analysis, wrote the manuscript, and reviewed and evaluated CT images, as well as provided patient care. YM performed statistical analysis and wrote the manuscript. TU and MF collected and analyzed the data. KN and MT engaged in patient care. KM planned, initiated, and designed the study; collected data; wrote the manuscript; and reviewed and evaluated CT images, as well as provided patient care.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Chiba, Japan

    Yoshiaki Abe, Tomotaka Ugai, Manabu Fujisawa, Kentaro Narita, Masami Takeuchi & Kosei Matsue

  2. Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan

    Tomotaka Ugai

  3. Division of Hematology, Saitama Medical Center, Jichi Medical University, Omiya, Japan

    Tomotaka Ugai

  4. Division of Hematology, Department of Medicine, University of Tsukuba, Ibaraki, Japan

    Manabu Fujisawa

  5. Department of Cardiology, Kameda Medical Center, Chiba, Japan

    Yuya Matsue

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  1. Yoshiaki Abe
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Correspondence to Kosei Matsue.

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Conflict of interest

YM is supported by JSPS (Japan Society for the Promotion of Science) Postdoctoral Fellowships for Research Abroad. The remaining authors declare that they have no conflict of interest.

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Abe, Y., Ugai, T., Fujisawa, M. et al. Prognostic implication of appendicular skeleton bone marrow abnormalities detected using low-dose multidetector computed tomography in patients with myelodysplastic syndrome. Leukemia 32, 2069–2073 (2018). https://doi.org/10.1038/s41375-018-0048-6

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