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Long-term pulmonary outcomes in BPD throughout the life-course

Journal of Perinatology (2024)Cite this article

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Abstract

Respiratory disease is one of the most common complications of preterm birth. Survivors of prematurity have increased risks of morbidities and mortalities independent of prematurity, and frequently require multiple medications, home respiratory support, and subspecialty care to maintain health. Although advances in neonatal and pulmonary care have improved overall survival, earlier gestational age, lower birth weight, chorioamnionitis and late onset sepsis continue to be major factors in the development of bronchopulmonary dysplasia. These early life events associated with prematurity can have respiratory consequences that persist into adulthood. Furthermore, after initial hospital discharge, air pollution, respiratory tract infections and socioeconomic status may modify lung growth trajectories and influence respiratory outcomes in later life. Given that the incidence of respiratory disease associated with prematurity remains stable or increased, there is a need for pediatric and adult providers to be familiar with the natural history, manifestations, and common complications of disease.

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Fig. 1: Causes of Airway obstruction.
Fig. 2: Airway obstruction in BPD across the lifespan.
Fig. 3: Pulmonary hypertension in BPD.

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Funding

Funding

This work was supported by a R03HD109442 (JMC, SAM), The funding sources had no involvement in the writing of the manuscript or the decision to submit.

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Authors and Affiliations

  1. Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA

    Joseph M. Collaco

  2. Division of Pediatric Pulmonology, Seattle Children’s Hospital, Seattle, WA, USA

    Laurie C. Eldredge

  3. Division of Pulmonary Medicine, Children’s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA

    Sharon A. McGrath-Morrow

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  1. Joseph M. Collaco
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  2. Laurie C. Eldredge
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  3. Sharon A. McGrath-Morrow
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Contributions

Joseph M. Collaco: contributed to the conception and design of the work, drafting and writing and editing of the final manuscript. Laurie C. Eldredge: contributed to the conception and design of the work, drafting and writing and editing of the final manuscript. Sharon A. McGrath-Morrow: to the conception and design of the work, drafting writing and editing of the final manuscript.

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Correspondence to Sharon A. McGrath-Morrow.

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Collaco, J.M., Eldredge, L.C. & McGrath-Morrow, S.A. Long-term pulmonary outcomes in BPD throughout the life-course. J Perinatol (2024). https://doi.org/10.1038/s41372-024-01957-9

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  • DOI: https://doi.org/10.1038/s41372-024-01957-9

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